Detailed view for OVOC5348

Basic information

TDR Targets ID: 989050
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 5.3683 | Length (AA): 416 | MW (Da): 47235 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02096  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0051205   protein insertion into membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130689)

Species Accession Gene Product
Brugia malayi Bm1_40820   Probable inner membrane protein OXA1L2
Candida albicans CaO19.3946   cytochrome oxidase
Candida albicans CaO19.11428   cytochrome oxidase
Caenorhabditis elegans CELE_Y55F3AR.1   Protein Y55F3AR.1
Drosophila melanogaster Dmel_CG4942   CG4942 gene product from transcript CG4942-RA
Echinococcus granulosus EgrG_000699300   Membrane insertion protein OxaA YidC
Echinococcus multilocularis EmuJ_000699300   Membrane insertion protein, OxaA YidC
Homo sapiens 285521   COX18 cytochrome c oxidase assembly factor
Loa Loa (eye worm) LOAG_04091   hypothetical protein
Mus musculus ENSMUSG00000035505   cytochrome c oxidase assembly protein 18
Onchocerca volvulus OVOC5348  
Saccharomyces cerevisiae YGR062C   Cox18p
Schistosoma japonicum Sjp_0059000   expressed protein
Schistosoma mansoni Smp_174130   cytochrome oxidase biogenesis protein (oxa1 mitochondrial)

Essentiality

OVOC5348 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y55F3AR.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC5348 (Onchocerca volvulus),
Title for this comment
Comment