Detailed view for OVOC8362

Basic information

TDR Targets ID: 989071
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 7.5651 | Length (AA): 275 | MW (Da): 30967 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00806  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0003723   RNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 462 5wzj (A) 216 640 11.00 0 1 0.8638 0.29
102 485 3k62 (A) 171 564 32.00 0 1 1.1438 -0.81
112 485 1m8z (A) 841 1166 33.00 0 1 1.0518 -0.63
118 485 3v71 (A) 87 451 33.00 0 1 1.1228 -0.7
228 498 5wzk (A) 121 448 21.00 0.34 0.98 0.4642 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171342)

Species Accession Gene Product
Brugia malayi Bm1_45615   Pumilio-family RNA binding repeat containing protein
Caenorhabditis elegans CELE_Y73B6BL.38   Protein PUF-11
Caenorhabditis elegans CELE_Y45F10A.2   Protein PUF-3
Loa Loa (eye worm) LOAG_00888   pumilio-family RNA binding repeat containing protein
Onchocerca volvulus OVOC8362  

Essentiality

OVOC8362 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y45F10A.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y45F10A.2 Caenorhabditis elegans sterile wormbase
CELE_Y73B6BL.38 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y73B6BL.38 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Beta-chymotrypsin 245 aa 24.2% 265 aa Compounds References
Rattus norvegicus Elastase 2A 271 aa 25.4% 236 aa Compounds References
Bos taurus Trypsin I 246 aa 21.0% 210 aa Compounds References
Oryctolagus cuniculus Thrombin 235 aa 23.4% 231 aa Compounds References
Sus scrofa Elastase 2A 269 aa 26.2% 237 aa Compounds References
Bos taurus Alpha-chymotrypsin 245 aa 22.3% 251 aa Compounds References
Rattus norvegicus Trypsin II 246 aa 20.8% 216 aa Compounds References
Sus scrofa Elastase 1 266 aa 20.9% 225 aa Compounds References
Rattus norvegicus Tryptase alpha/beta-1 273 aa 20.4% 245 aa Compounds References
Sus scrofa Pancreatic elastase 269 aa 26.2% 237 aa Compounds References
Rattus norvegicus Anionic trypsin-1 246 aa 21.5% 214 aa Compounds References
Sus scrofa Trypsin 231 aa 21.2% 212 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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