Detailed view for OVOC11760

Basic information

TDR Targets ID: 990133
Onchocerca volvulus, Putative neuronal RhoA GEF protein
Source Database / ID:  Wormbase Parasite  

pI: 7.9069 | Length (AA): 1021 | MW (Da): 114949 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169  
PF00621  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005089   Rho guanyl-nucleotide exchange factor activity  
GO:0035023   regulation of Rho protein signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
125 552 3ky9 (B) 117 505 24.00 0.0000016 1 0.717162 0.93
178 396 4gyv (A) 536 747 17.00 0 1 0.652223 -1.31
227 368 2rgn (B) 205 326 35.00 0.00016 0.37 0.375162 0.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_137783)

Species Accession Gene Product
Brugia malayi Bm1_29235   PH domain containing protein
Caenorhabditis elegans CELE_Y95B8A.12   Protein Y95B8A.12, isoform F
Homo sapiens ENSG00000187510   pleckstrin homology domain containing, family G (with RhoGef domain) member 7
Loa Loa (eye worm) LOAG_00425   hypothetical protein
Onchocerca volvulus OVOC11760   Putative neuronal RhoA GEF protein
Schistosoma japonicum Sjp_0038480   Pleckstrin homology domain-containing family G member 7, putative
Schistosoma mansoni Smp_176920   neuronal RhoA GEF protein
Schmidtea mediterranea mk4.004021.00   Putative neuronal RhoA GEF protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 26.8% 153 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.8% 262 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 24.7% 304 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 31.8% 198 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 24.3% 304 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC11760 (Onchocerca volvulus), Putative neuronal RhoA GEF protein
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