Detailed view for OVOC9077

Basic information

TDR Targets ID: 990139
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 4.9036 | Length (AA): 447 | MW (Da): 50024 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129489)

Species Accession Gene Product
Brugia malayi Bm1_05450   GTP-ase activating protein for Arf containing protein
Caenorhabditis elegans CELE_Y39A1A.15   Protein CNT-2, isoform C
Drosophila melanogaster Dmel_CG31811   Centaurin gamma 1A
Echinococcus granulosus EgrG_000894200   arf GAP with GTPase ANK repeat and PH
Echinococcus multilocularis EmuJ_000894200   arf GAP with GTPase, ANK repeat and PH
Homo sapiens ENSG00000172650   ArfGAP with GTPase domain, ankyrin repeat and PH domain 5
Homo sapiens ENSG00000204149   ArfGAP with GTPase domain, ankyrin repeat and PH domain 6
Homo sapiens 101060581   arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4-like
Homo sapiens ENSG00000133612   ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Homo sapiens ENSG00000204172   ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
Homo sapiens 728127   ArfGAP with GTPase domain, ankyrin repeat and PH domain 10
Homo sapiens 102725500   arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4-like
Homo sapiens ENSG00000157985   ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Homo sapiens 119385   ankyrin repeat and GTPase domain Arf GTPase activating protein 11
Homo sapiens ENSG00000135439   ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Homo sapiens ENSG00000188234   ArfGAP with GTPase domain, ankyrin repeat and PH domain 4
Loa Loa (eye worm) LOAG_14747   hypothetical protein
Loa Loa (eye worm) LOAG_14291   hypothetical protein
Loa Loa (eye worm) LOAG_10171   hypothetical protein
Mus musculus ENSMUSG00000025422   ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Mus musculus ENSMUSG00000055013   ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Mus musculus ENSMUSG00000023353   ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
Onchocerca volvulus OVOC9077  
Schistosoma japonicum Sjp_0117780   Centaurin-gamma-1A, putative
Schistosoma japonicum Sjp_0085760   Centaurin-gamma-2, putative
Schistosoma mansoni Smp_052420   centaurin/arf-related
Schmidtea mediterranea mk4.045442.00   Centaurin-gamma-1A
Schmidtea mediterranea mk4.001437.00  
Schmidtea mediterranea mk4.001437.01   Centaurin-gamma-1A
Schmidtea mediterranea mk4.008024.00   Centaurin-gamma-1A
Schmidtea mediterranea mk4.015099.01  
Schmidtea mediterranea mk4.029517.01   Centaurin-gamma-1A
Schmidtea mediterranea mk4.038122.00   Centaurin-gamma-1A
Schmidtea mediterranea mk4.011066.02  
Schmidtea mediterranea mk4.025469.00   Centaurin-gamma-1A
Schmidtea mediterranea mk4.019914.00  
Schmidtea mediterranea mk4.022603.00  
Schmidtea mediterranea mk4.029517.00   Centaurin-gamma-1A
Schmidtea mediterranea mk4.000849.07  

Essentiality

OVOC9077 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y39A1A.15 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin 445 aa 36.2% 445 aa Compounds References
Bos taurus Tubulin beta chain 445 aa 36.2% 445 aa Compounds References
Sus scrofa Tubulin 445 aa 36.2% 445 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC9077 (Onchocerca volvulus),
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