Detailed view for OVOC7725

Basic information

TDR Targets ID: 990188
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.5434 | Length (AA): 375 | MW (Da): 43564 | Paralog Number: 30

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10328  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 213 6ibl (A) 1104 241 14.00 0 0.05 1.06039 0.45
99 183 5kbn (A) 36 116 32.00 0.1 0.02 0.444749 1.45

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_171302)

Species Accession Gene Product
Brugia malayi Bm1_25485   hypothetical protein
Brugia malayi Bm1_25480   Serpentine receptor, class x protein 12
Caenorhabditis elegans CELE_K09D9.10   Protein SRX-62
Caenorhabditis elegans CELE_K07C6.7   Protein SRX-64
Loa Loa (eye worm) LOAG_07731   hypothetical protein
Loa Loa (eye worm) LOAG_14171   hypothetical protein
Loa Loa (eye worm) LOAG_13012   hypothetical protein
Loa Loa (eye worm) LOAG_08029   hypothetical protein
Loa Loa (eye worm) LOAG_14001   hypothetical protein
Loa Loa (eye worm) LOAG_12989   hypothetical protein
Loa Loa (eye worm) LOAG_12194   hypothetical protein
Loa Loa (eye worm) LOAG_14508   hypothetical protein
Loa Loa (eye worm) LOAG_14510   hypothetical protein
Loa Loa (eye worm) LOAG_13010   hypothetical protein
Loa Loa (eye worm) LOAG_14407   hypothetical protein
Loa Loa (eye worm) LOAG_10854   hypothetical protein
Loa Loa (eye worm) LOAG_15619   hypothetical protein
Loa Loa (eye worm) LOAG_12231   hypothetical protein
Onchocerca volvulus OVOC12942  
Onchocerca volvulus OVOC12678  
Onchocerca volvulus OVOC3382  
Onchocerca volvulus OVOC12395  
Onchocerca volvulus OVOC12842  
Onchocerca volvulus OVOC12679  
Onchocerca volvulus OVOC7473  
Onchocerca volvulus OVOC12198  
Onchocerca volvulus OVOC12511  
Onchocerca volvulus OVOC8081  
Onchocerca volvulus OVOC12227  
Onchocerca volvulus OVOC12730  
Onchocerca volvulus OVOC12199  
Onchocerca volvulus OVOC12813  
Onchocerca volvulus OVOC8040  
Onchocerca volvulus OVOC12958  
Onchocerca volvulus OVOC3802  
Onchocerca volvulus OVOC11966  
Onchocerca volvulus OVOC7504  
Onchocerca volvulus OVOC12889  
Onchocerca volvulus OVOC12583  
Onchocerca volvulus OVOC12202  
Onchocerca volvulus OVOC12204  
Onchocerca volvulus OVOC12765  
Onchocerca volvulus OVOC8080  
Onchocerca volvulus OVOC12665  
Onchocerca volvulus OVOC7725  
Onchocerca volvulus OVOC12201  
Onchocerca volvulus OVOC12728  
Onchocerca volvulus OVOC12197  
Onchocerca volvulus OVOC7503  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 27.3% 172 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 29.7% 128 aa Compounds References
Bos taurus Casein kinase I isoform alpha 325 aa 29.2% 295 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.0% 273 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC7725 (Onchocerca volvulus),
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