Detailed view for OVOC5203

Basic information

TDR Targets ID: 990652
Onchocerca volvulus, Phospholipase d-related homolog
Source Database / ID:  Wormbase Parasite  

pI: 8.5208 | Length (AA): 457 | MW (Da): 52474 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
37 112 1byr (A) 82 151 20.00 0.2 0.65 0.436053 0.58

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Somatostatin receptor 363 aa 21.0% 295 aa Compounds References
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor 354 aa 22.9% 310 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 20.9% 326 aa Compounds References
Rattus norvegicus Cannabinoid CB2 receptor 360 aa 23.3% 309 aa Compounds References
Rattus norvegicus Somatostatin receptor 5 363 aa 21.0% 295 aa Compounds References
Rattus norvegicus Vasopressin V1b receptor 425 aa 20.2% 357 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 20.9% 326 aa Compounds References
Cavia porcellus Serotonin 7 (5-HT7) receptor 446 aa 21.5% 363 aa Compounds References
Rattus norvegicus Neurokinin 2 receptor 390 aa 23.5% 379 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 25.6% 82 aa Compounds References
Rattus norvegicus Vasopressin V1 receptor 425 aa 20.2% 357 aa Compounds References
Rattus norvegicus Orexin receptor 1 416 aa 22.4% 344 aa Compounds References
Rattus norvegicus Serotonin 4 (5-HT4) receptor 406 aa 19.3% 389 aa Compounds References
Cricetulus griseus 5-hydroxytryptamine receptor 1B 386 aa 19.3% 348 aa Compounds References
Bos taurus Beta-2 adrenergic receptor 418 aa 24.3% 411 aa Compounds References
Xenopus laevis Melatonin receptor 1C 420 aa 19.3% 363 aa Compounds References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor 386 aa 18.6% 350 aa Compounds References
Canis lupus familiaris Beta-2 adrenergic receptor 415 aa 22.8% 338 aa Compounds References
Mesocricetus auratus Beta-2 adrenergic receptor 418 aa 24.3% 358 aa Compounds References
Rattus norvegicus Oxytocin receptor 388 aa 20.0% 330 aa Compounds References
Cavia porcellus Cholecystokinin A receptor 430 aa 20.9% 359 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 17.8% 304 aa Compounds References
Rattus norvegicus Vasopressin V2 receptor 371 aa 19.0% 336 aa Compounds References
Rattus norvegicus Melanocortin receptor 5 325 aa 20.9% 321 aa Compounds References
Rattus norvegicus Beta-2 adrenergic receptor 418 aa 23.5% 392 aa Compounds References
Gorilla gorilla Serotonin 1b (5-HT1b) receptor 390 aa 19.3% 378 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 20.8% 317 aa Compounds References
Canis lupus familiaris Somatostatin receptor subtype 3 425 aa 17.6% 374 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 18.8% 304 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 18.4% 304 aa Compounds References
Human cytomegalovirus G protein-coupled receptor 354 aa 22.9% 310 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 23.0% 331 aa Compounds References
Rattus norvegicus Kappa opioid receptor 380 aa 19.4% 309 aa Compounds References
Bos taurus Rhodopsin 348 aa 22.3% 314 aa Compounds References
Cavia porcellus Beta-2 adrenergic receptor 418 aa 22.9% 385 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 21.7% 332 aa Compounds References
Rattus norvegicus Serotonin (5-HT) receptor 386 aa 18.6% 350 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 23.0% 331 aa Compounds References
Rattus norvegicus Neuropeptide FF receptor 2 417 aa 19.8% 404 aa Compounds References
Rattus norvegicus Somatostatin receptor 1 391 aa 21.3% 334 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 19.7% 295 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 20.8% 317 aa Compounds References
Cavia porcellus Serotonin 4 (5-HT4) receptor 388 aa 17.6% 404 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 19.1% 304 aa Compounds References
Gallus gallus Oxytocin-like receptor 391 aa 22.4% 322 aa Compounds References
Rattus norvegicus Vasopressin receptor 425 aa 20.2% 357 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 7b 358 aa 19.8% 318 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5203 (Onchocerca volvulus), Phospholipase d-related homolog
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