Detailed view for Rv2606c

Basic information

TDR Targets ID: 9910
Mycobacterium tuberculosis, Possible pyridoxine biosynthesis protein SnzP
Source Database / ID:  Tuberculist 

pI: 5.0501 | Length (AA): 299 | MW (Da): 31365 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01680   SOR/SNZ family

Gene Ontology

Mouse over links to read term descriptions.
GO:0042823   pyridoxal phosphate biosynthetic process  
GO:0042819   vitamin B6 biosynthetic process  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

Vitamin B6 metabolism (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 274 4jdy (A) 11 274 99.99 0 1 2.09204 -1.16

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 4JDY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_128957)

Species Accession Gene Product
Arabidopsis thaliana AT5G01410   Pyridoxal biosynthesis protein PDX1.3
Arabidopsis thaliana AT2G38230   Pyridoxal biosynthesis protein PDX1.1
Candida albicans CaO19.2947   stationary-phase-induced
Candida albicans CaO19.10464   stationary-phase-induced
Dictyostelium discoideum DDB_G0288299   vitamin B6 biosynthesis family protein
Mycobacterium leprae ML0450c   Possible pyridoxine biosynthesis protein SnzP
Mycobacterium tuberculosis Rv2606c   Possible pyridoxine biosynthesis protein SnzP
Mycobacterium ulcerans MUL_3250   pyridoxal biosynthesis lyase PdxS
Neospora caninum NCLIV_051000   Ethylene-inducible protein hever, related
Oryza sativa 4347937   Os10g0100700
Oryza sativa 4351233   Os11g0708500
Oryza sativa 4342162   Os07g0100200
Plasmodium berghei PBANKA_1120200   pyridoxine biosynthesis protein PDX1, putative
Plasmodium falciparum PF3D7_0621200   pyridoxine biosynthesis protein PDX1
Plasmodium knowlesi PKNH_1129000   pyridoxine biosynthesis protein PDX1, putative
Plasmodium vivax PVX_114180   pyridoxine biosynthesis protein PDX1, putative
Plasmodium yoelii PY04475   ethylene-inducible protein hever
Saccharomyces cerevisiae YNL333W   pyridoxine biosynthesis protein SNZ2
Saccharomyces cerevisiae YMR096W   pyridoxine biosynthesis protein SNZ1
Saccharomyces cerevisiae YFL059W   pyridoxine biosynthesis protein SNZ3
Schmidtea mediterranea mk4.000858.13  
Toxoplasma gondii TGME49_237140   ethylene inducible protein, putative

Essentiality

Rv2606c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1120200 Plasmodium berghei Dispensable plasmo
TGME49_237140 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv2606c (Mycobacterium tuberculosis), Possible pyridoxine biosynthesis protein SnzP
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