pI: 10.1364 |
Length (AA): 155 |
MW (Da): 16808 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
166 | 240 | 4w6v (A) | 235 | 311 | 28.00 | 0.82 | 0.02 | 0.186332 | 1.97 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126850)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G26740 | hypothetical protein |
Arabidopsis thaliana | AT3G05940 | hypothetical protein |
Arabidopsis thaliana | AT1G77220 | hypothetical protein |
Babesia bovis | BBOV_II005420 | hypothetical protein |
Brugia malayi | Bm1_40780 | MAP kinase activating protein C22orf5 |
Candida albicans | CaO19.6981 | potential membrane protein similar to S. cerevisiae YKR051W |
Caenorhabditis elegans | CELE_F40E10.6 | Protein F40E10.6 |
Cryptosporidium hominis | Chro.20450 | hypothetical protein |
Cryptosporidium parvum | cgd2_4200 | hypothetical protein |
Dictyostelium discoideum | DDB_G0291287 | transmembrane protein 184D |
Dictyostelium discoideum | DDB_G0279555 | transmembrane protein 184C |
Dictyostelium discoideum | DDB_G0304961 | transmembrane protein 184E |
Dictyostelium discoideum | DDB_G0276041 | transmembrane protein 184B |
Dictyostelium discoideum | DDB_G0284525 | transmembrane protein 184A |
Drosophila melanogaster | Dmel_CG5850 | CG5850 gene product from transcript CG5850-RD |
Drosophila melanogaster | Dmel_CG12004 | CG12004 gene product from transcript CG12004-RD |
Echinococcus granulosus | EgrG_000744500 | transmembrane protein 184c |
Echinococcus granulosus | EgrG_000090300 | transmembrane protein 184A |
Entamoeba histolytica | EHI_153730 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000090300 | transmembrane protein 184A |
Echinococcus multilocularis | EmuJ_000744500 | transmembrane protein 184c |
Homo sapiens | 55751 | transmembrane protein 184C |
Homo sapiens | ENSG00000164855 | transmembrane protein 184A |
Homo sapiens | ENSG00000198792 | transmembrane protein 184B |
Leishmania braziliensis | LbrM.11.0940 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.35.7050 | hypothetical protein, conserved,f2o10.10 protein-like protein |
Leishmania donovani | LdBPK_367000.1 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_111190.1 | Organic solute transporter Ostalpha, putative |
Leishmania infantum | LinJ.11.1190 | hypothetical protein, conserved |
Leishmania infantum | LinJ.36.7000 | hypothetical protein, conserved,f2o10.10 protein-like protein |
Leishmania major | LmjF.36.6690 | hypothetical protein, conserved,f2o10.10 protein-like protein |
Leishmania major | LmjF.11.1200 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.11.1200 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.6690 | hypothetical protein, conserved,f2o10.10 protein-like protein |
Loa Loa (eye worm) | LOAG_02862 | MAP kinase activating protein C22orf5 |
Mus musculus | ENSMUSG00000031617 | transmembrane protein 184C |
Mus musculus | ENSMUSG00000036687 | transmembrane protein 184a |
Mus musculus | ENSMUSG00000009035 | transmembrane protein 184b |
Neospora caninum | NCLIV_043640 | Transmembrane protein 184A, related |
Neospora caninum | NCLIV_034350 | ACR261Cp, related |
Oryza sativa | 4342119 | Os06g0726600 |
Oryza sativa | 4339325 | Os05g0516900 |
Oryza sativa | 4330269 | Os02g0670000 |
Oryza sativa | 4342821 | Os07g0244300 |
Onchocerca volvulus | OVOC5337 |
|
Saccharomyces cerevisiae | YKR051W | hypothetical protein |
Schistosoma japonicum | Sjp_0030840 | Transmembrane protein 184B, putative |
Schistosoma mansoni | Smp_126920 | organic solute transporter |
Schistosoma mansoni | Smp_158190 | organic solute transporter |
Schmidtea mediterranea | mk4.003246.04 | Putative organic solute transporter |
Schmidtea mediterranea | mk4.000924.03 | Transmembrane protein 184C |
Schmidtea mediterranea | mk4.000843.13 | Putative organic solute transporter |
Trypanosoma brucei gambiense | Tbg972.10.9750 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.7970 | Organic solute transporter Ostalpha, putative |
Trypanosoma congolense | TcIL3000_10_6840 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506297.340 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.508041.20 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.506247.290 | Organic solute transporter Ostalpha, putative |
Toxoplasma gondii | TGME49_210380 | hypothetical protein |
Toxoplasma gondii | TGME49_273200 | hypothetical protein |
Theileria parva | TP02_0493 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.7970 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.7970 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.7970 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.7970 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_210380 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_273200 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_210380 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_273200 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.