Detailed view for OVOC2046

Basic information

TDR Targets ID: 991380
Onchocerca volvulus, Mitochondrial fission 1 protein homolog
Source Database / ID:  Wormbase Parasite  

pI: 8.2375 | Length (AA): 210 | MW (Da): 23985 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14852  
PF14853  

Gene Ontology

Mouse over links to read term descriptions.
GO:0000266   mitochondrial fission  
GO:0005515   protein binding  

Metabolic Pathways

Mitophagy - animal (KEGG)
Mitophagy - yeast (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 143 1pc2 (A) 1 141 41.00 0 1 1.27743 0.07
31 108 3qky (A) 31 106 17.00 0 0.67 0.734102 -1.13
40 116 5waq (A) 39 118 23.00 0.12 0.8 0.811884 -1.07

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129200)

Species Accession Gene Product
Arabidopsis thaliana AT3G57090   protein BIGYIN1
Arabidopsis thaliana AT5G12390   hypothetical protein
Babesia bovis BBOV_II004740   hypothetical protein
Brugia malayi Bm1_26785   fis1-related protein
Candida albicans CaO19_7111   hypothetical protein
Candida albicans CaO19.7111   Mitochondrial fission
Caenorhabditis elegans CELE_F41G3.4   Protein FIS-1
Caenorhabditis elegans CELE_F13B9.8   Protein FIS-2, isoform A
Dictyostelium discoideum DDB_G0280367   hypothetical protein
Drosophila melanogaster Dmel_CG17510   CG17510 gene product from transcript CG17510-RA
Echinococcus granulosus EgrG_000225700   mitochondrial fission 1 protein
Echinococcus multilocularis EmuJ_000225700   mitochondrial fission 1 protein
Homo sapiens ENSG00000214253   fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Loa Loa (eye worm) LOAG_10996   hypothetical protein
Mus musculus ENSMUSG00000019054   fission 1 (mitochondrial outer membrane) homolog (yeast)
Neospora caninum NCLIV_024600   hypothetical protein
Oryza sativa 4325741   Os01g0951800
Oryza sativa 4338647   Os05g0383000
Oryza sativa 9266461   Os03g0356484
Onchocerca volvulus OVOC2046   Mitochondrial fission 1 protein homolog
Plasmodium berghei PBANKA_1340700   mitochondrial fission 1 protein, putative
Plasmodium falciparum PF3D7_1325600   mitochondrial fission 1 protein, putative
Plasmodium knowlesi PKNH_1203200   mitochondrial fission 1 protein, putative
Plasmodium vivax PVX_116600   mitochondrial fission 1 protein, putative
Plasmodium yoelii PY02026   hypothetical protein
Saccharomyces cerevisiae YIL065C   Fis1p
Schistosoma japonicum Sjp_0306500   IPR011990,Tetratricopeptide-like helical,domain-containing
Schistosoma japonicum Sjp_0027450   Mitochondrial fission 1 protein, putative
Schistosoma japonicum Sjp_0204890   Mitochondrial fission 1 protein, putative
Schistosoma mansoni Smp_182780   hypothetical protein
Schistosoma mansoni Smp_032230   hypothetical protein
Schmidtea mediterranea mk4.000660.08   Mitochondrial fission 1 protein
Toxoplasma gondii TGME49_263323   tetratricopeptide repeat protein 11, putative
Theileria parva TP02_0282   hypothetical protein

Essentiality

OVOC2046 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F41G3.4 Caenorhabditis elegans embryonic lethal wormbase
TGME49_263323 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2046 (Onchocerca volvulus), Mitochondrial fission 1 protein homolog
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