Detailed view for OVOC6501

Basic information

TDR Targets ID: 991387
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.4015 | Length (AA): 350 | MW (Da): 41363 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09813  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130049)

Species Accession Gene Product
Brugia malayi Bm1_52170   hypothetical protein
Brugia malayi Bm1_52175   Protein kinase domain containing protein
Candida albicans CaO19.3776   MAP kinase kinase kinase
Candida albicans CaO19.11257   MAP kinase kinase kinase
Candida albicans CaO19.3775   similar to MAP kinase kinase kinase
Caenorhabditis elegans CELE_B0414.7   Protein MTK-1, isoform A
Drosophila melanogaster Dmel_CG7717   CG7717 gene product from transcript CG7717-RB
Homo sapiens ENSG00000085511   mitogen-activated protein kinase kinase kinase 4
Loa Loa (eye worm) LOAG_05861   STE/STE11/MEKK4 protein kinase
Loa Loa (eye worm) LOAG_05860   hypothetical protein
Mus musculus ENSMUSG00000014426   mitogen-activated protein kinase kinase kinase 4
Onchocerca volvulus OVOC6501  
Saccharomyces cerevisiae YNR031C   Ssk2p
Saccharomyces cerevisiae YCR073C   Ssk22p
Schmidtea mediterranea mk4.000879.02   Mitogen-activated protein kinase kinase kinase 4
Schmidtea mediterranea mk4.010967.02  

Essentiality

OVOC6501 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_B0414.7 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens mitogen-activated protein kinase kinase kinase 4 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier OVOC6501 (Onchocerca volvulus),
Title for this comment
Comment