Detailed view for OVOC10731

Basic information

TDR Targets ID: 991610
Onchocerca volvulus, Acetylcholine receptor subunit alpha-type des-2 homolog
Source Database / ID:  Wormbase Parasite  

pI: 7.8426 | Length (AA): 570 | MW (Da): 66284 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 266 3sio (A) 0 207 21.00 0 0.96 0.412829 1.12
26 239 2qc1 (B) 1 208 20.00 0.00031 0.35 0.476012 0.67
27 356 4pir (A) 10 304 35.00 0 0.92 0.660222 1.33
29 266 4zjs (A) 4 207 23.00 0 1 0.45849 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit 502 aa 29.6% 530 aa Compounds References
Aplysia californica Soluble acetylcholine receptor 236 aa 23.9% 222 aa Compounds References
Macaca mulatta Neuronal acetylcholine receptor subunit alpha-7 502 aa 29.6% 521 aa Compounds References
Torpedo californica Acetylcholine receptor protein alpha chain 461 aa 29.0% 428 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-2 subunit 511 aa 26.9% 527 aa Compounds References
Rattus norvegicus Serotonin 3 (5-HT3) receptor 483 aa 24.8% 464 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor subunit alpha-6 493 aa 26.4% 516 aa Compounds References
Lymnaea stagnalis Acetylcholine-binding protein 229 aa 20.9% 225 aa Compounds References
Rattus norvegicus Serotonin 3a (5-HT3a) receptor 483 aa 24.8% 464 aa Compounds References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-9 subunit 479 aa 29.9% 422 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC10731 (Onchocerca volvulus), Acetylcholine receptor subunit alpha-type des-2 homolog
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