Detailed view for OVOC5886

Basic information

TDR Targets ID: 991773
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.6531 | Length (AA): 444 | MW (Da): 51599 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00628  
PF12998  

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  
GO:0016568   chromatin modification  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 81 5mto (A) 4 103 44.00 0.00000000029 0.86 0.754043 -1.27
134 218 1weu (A) 7 90 52.00 0 1 0.842364 0.94
156 218 1wes (A) 8 70 62.00 0 1 0.99415 -0.44
160 219 1x4i (A) 2 61 58.00 0 1 1.01576 -1.19
166 211 2mum (A) 224 269 54.00 0.000023 0.99 0.827357 -0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128635)

Species Accession Gene Product
Arabidopsis thaliana AT3G24010   PHD finger protein ING1
Brugia malayi Bm1_08060   PHD-finger family protein
Candida albicans CaO19.8497   potential PHD finger protein similar to S. cerevisiae YNG2 (YHR090C) NuA4 histone acetyltransferase complex component
Candida albicans CaO19.878   potential PHD finger protein similar to S. cerevisiae YNG2 (YHR090C) NuA4 histone acetyltransferase complex component
Dictyostelium discoideum DDB_G0284411   PHD zinc finger-containing protein
Drosophila melanogaster Dmel_CG9293   CG9293 gene product from transcript CG9293-RB
Echinococcus granulosus EgrG_001048400   inhibitor of growth protein 4
Echinococcus granulosus EgrG_001048500   dna repair protein swi5
Echinococcus granulosus EgrG_000221500   inhibitor of growth protein 3
Echinococcus multilocularis EmuJ_001048400   inhibitor of growth protein 4
Echinococcus multilocularis EmuJ_001048500   dna repair protein swi5
Homo sapiens ENSG00000111653   inhibitor of growth family, member 4
Homo sapiens ENSG00000168395   inhibitor of growth family, member 5
Loa Loa (eye worm) LOAG_08679   PHD-finger family protein
Mus musculus ENSMUSG00000030330   inhibitor of growth family, member 4
Mus musculus ENSMUSG00000026283   inhibitor of growth family, member 5
Oryza sativa 4331591   Os03g0143600
Onchocerca volvulus OVOC5886  
Saccharomyces cerevisiae YHR090C   Yng2p
Schistosoma japonicum Sjp_0214440   expressed protein
Schistosoma japonicum Sjp_0214430   Inhibitor of growth protein 4, putative
Schistosoma mansoni Smp_120980   inhibitor of growth family member 5
Schmidtea mediterranea mk4.000093.03   Inhibitor of growth protein 3
Schmidtea mediterranea mk4.022181.00  
Schmidtea mediterranea mk4.000263.08  
Schmidtea mediterranea mk4.011423.00   Ing-related
Schmidtea mediterranea mk4.021903.00  
Schmidtea mediterranea mk4.000093.00   Inhibitor of growth protein 3
Schmidtea mediterranea mk4.000430.07  
Trichomonas vaginalis TVAG_021600   inhibitor of growth, putative
Trichomonas vaginalis TVAG_385560   inhibitor of growth, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Chlamydomonas reinhardtii Photosystem II protein D1 145 aa 28.3% 120 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC5886 (Onchocerca volvulus),
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