Detailed view for OVOC3119

Basic information

TDR Targets ID: 992640
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.7011 | Length (AA): 521 | MW (Da): 60800 | Paralog Number: 35

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
26 187 2fds (A) 144 323 30.00 0.53 0.59 0.640357 0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_214610)

Species Accession Gene Product
Brugia malayi Bm1_26525   hypothetical protein
Brugia malayi Bm1_12720   hypothetical protein
Loa Loa (eye worm) LOAG_06816   hypothetical protein
Loa Loa (eye worm) LOAG_06317   hypothetical protein
Loa Loa (eye worm) LOAG_13861   hypothetical protein
Loa Loa (eye worm) LOAG_13867   hypothetical protein
Loa Loa (eye worm) LOAG_12232   hypothetical protein
Loa Loa (eye worm) LOAG_12904   hypothetical protein
Loa Loa (eye worm) LOAG_14032   hypothetical protein
Loa Loa (eye worm) LOAG_13199   hypothetical protein
Loa Loa (eye worm) LOAG_13986   hypothetical protein
Loa Loa (eye worm) LOAG_11742   hypothetical protein
Loa Loa (eye worm) LOAG_11697   hypothetical protein
Loa Loa (eye worm) LOAG_15994   hypothetical protein
Loa Loa (eye worm) LOAG_09708   hypothetical protein
Loa Loa (eye worm) LOAG_09803   hypothetical protein
Loa Loa (eye worm) LOAG_11685   hypothetical protein
Loa Loa (eye worm) LOAG_13723   hypothetical protein
Onchocerca volvulus OVOC9391  
Onchocerca volvulus OVOC9523  
Onchocerca volvulus OVOC1851  
Onchocerca volvulus OVOC12504  
Onchocerca volvulus OVOC2311  
Onchocerca volvulus OVOC1909  
Onchocerca volvulus OVOC12522  
Onchocerca volvulus OVOC12668  
Onchocerca volvulus OVOC12788  
Onchocerca volvulus OVOC9179  
Onchocerca volvulus OVOC12205  
Onchocerca volvulus OVOC12446  
Onchocerca volvulus OVOC11710  
Onchocerca volvulus OVOC9401  
Onchocerca volvulus OVOC1796  
Onchocerca volvulus OVOC1797  
Onchocerca volvulus OVOC3119  
Onchocerca volvulus OVOC9146  
Onchocerca volvulus OVOC1497  
Onchocerca volvulus OVOC12162  
Onchocerca volvulus OVOC12562  
Onchocerca volvulus OVOC12806  
Onchocerca volvulus OVOC9439  
Onchocerca volvulus OVOC12761  
Onchocerca volvulus OVOC6173  
Onchocerca volvulus OVOC12206  
Onchocerca volvulus OVOC12338  
Onchocerca volvulus OVOC9452  
Onchocerca volvulus OVOC46  
Onchocerca volvulus OVOC12658  
Onchocerca volvulus OVOC1323  
Onchocerca volvulus OVOC12687  
Onchocerca volvulus OVOC12882  
Onchocerca volvulus OVOC1892  
Onchocerca volvulus OVOC12787  
Onchocerca volvulus OVOC9284  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus GABA A receptor alpha-6/beta-2/gamma-2 466 aa 26.3% 422 aa Compounds References
Rattus norvegicus Glycine receptor subunit alpha-2 452 aa 27.6% 427 aa Compounds References
Rattus norvegicus GABA receptor alpha-1 subunit 455 aa 27.9% 438 aa Compounds References
Rattus norvegicus GABA-A receptor; anion channel 467 aa 25.7% 447 aa Compounds References
Rattus norvegicus GABA receptor alpha-6 subunit 453 aa 25.8% 458 aa Compounds References
Rattus norvegicus GABA A receptor alpha-3/beta-2/gamma-2 493 aa 26.5% 442 aa Compounds References
Rattus norvegicus GABA receptor alpha-5 subunit 464 aa 26.8% 436 aa Compounds References
Rattus norvegicus GABA receptor alpha-2 subunit 451 aa 27.0% 437 aa Compounds References
Rattus norvegicus GABA receptor alpha-3 subunit 493 aa 26.5% 442 aa Compounds References
Rattus norvegicus Glycine receptor 496 aa 27.3% 444 aa Compounds References
Rattus norvegicus GABA receptor gamma-1 subunit 465 aa 25.9% 424 aa Compounds References
Rattus norvegicus GABA A receptor alpha-2/beta-2/gamma-2 451 aa 27.0% 437 aa Compounds References
Rattus norvegicus GABA A receptor alpha-5/beta-3/gamma-2 473 aa 25.9% 451 aa Compounds References
Rattus norvegicus GABA-A receptor; alpha-1/beta-2/gamma-2 455 aa 27.9% 438 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC3119 (Onchocerca volvulus),
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