Detailed view for OVOC2573

Basic information

TDR Targets ID: 993152
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 10.8959 | Length (AA): 383 | MW (Da): 44422 | Paralog Number: 8169

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Serotonin 1b (5-HT1b) receptor 150 aa 21.6% 153 aa Compounds References
Rattus norvegicus Serotonin 5b (5-HT5b) receptor 370 aa 23.3% 318 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 2 381 aa 23.5% 315 aa Compounds References
Macaca mulatta B1 bradykinin receptor 352 aa 25.0% 284 aa Compounds References
Rattus norvegicus Histamine H2 receptor 358 aa 21.9% 301 aa Compounds References
Macaca mulatta C-C chemokine receptor type 5 352 aa 25.1% 303 aa Compounds References
Rattus norvegicus Galanin receptor 2 372 aa 25.4% 307 aa Compounds References
Rattus norvegicus Succinate receptor 1 317 aa 21.5% 265 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 4 375 aa 23.7% 325 aa Compounds References
Rattus norvegicus Pyrimidinergic receptor P2Y4 361 aa 21.7% 304 aa Compounds References
Meleagris gallopavo P2Y purinoceptor 1 362 aa 22.3% 309 aa Compounds References
Cavia porcellus mu/kappa opioid receptor 380 aa 24.2% 310 aa Compounds References
Sus scrofa A1 adenosine receptor 326 aa 21.5% 321 aa Compounds References
Macaca mulatta C-X-C chemokine receptor type 4 352 aa 21.7% 322 aa Compounds References
Rattus norvegicus Vasopressin V2 receptor 371 aa 22.5% 315 aa Compounds References
Cavia porcellus Adenosine A1 receptor 326 aa 20.4% 328 aa Compounds References
Cavia porcellus Nociceptin receptor 370 aa 25.3% 332 aa Compounds References
Human cytomegalovirus G protein-coupled receptor 354 aa 25.2% 298 aa Compounds References
Oryctolagus cuniculus Bradykinin B1 receptor 352 aa 24.0% 325 aa Compounds References
Sus scrofa Angiotensin type II receptor 137 aa 22.2% 144 aa Compounds References
Rattus norvegicus Hydroxycarboxylic acid receptor 2 360 aa 21.9% 342 aa Compounds References
Cavia porcellus Kappa opioid receptor 380 aa 24.2% 310 aa Compounds References
Sus scrofa Delta opioid receptor 228 aa 26.0% 223 aa Compounds References
Cavia porcellus Mu opioid receptor 98 aa 24.0% 96 aa Compounds References
Rattus norvegicus Nociceptin receptor 367 aa 25.4% 334 aa Compounds References
Rattus norvegicus Somatostatin receptor 2 369 aa 26.1% 299 aa Compounds References
Rattus norvegicus C-C chemokine receptor type 1 355 aa 23.5% 298 aa Compounds References
Bos taurus Adenosine A1 receptor 326 aa 20.2% 326 aa Compounds References
Rattus norvegicus Protein Gpr39 298 aa 21.8% 248 aa Compounds References
Bos taurus 5-hydroxytryptamine 1D receptor 119 aa 21.4% 103 aa Compounds References
Canis lupus familiaris Adenosine receptor A3 314 aa 19.7% 300 aa Compounds References
Rattus norvegicus Adenosine A3 receptor 320 aa 20.6% 282 aa Compounds References
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor 363 aa 23.8% 311 aa Compounds References
Cavia porcellus Platelet activating factor receptor 342 aa 21.7% 295 aa Compounds References
Rattus norvegicus C-X-C chemokine receptor type 4 349 aa 22.7% 326 aa Compounds References
Rattus norvegicus G protein-coupled receptor 80 337 aa 22.4% 286 aa Compounds References
Bos taurus Rhodopsin 348 aa 23.0% 291 aa Compounds References
Sus scrofa Vasopressin V2 receptor 370 aa 22.7% 343 aa Compounds References
Oryctolagus cuniculus Adenosine A1 receptor 328 aa 18.6% 339 aa Compounds References
Oryctolagus cuniculus Adenosine A3 receptor 319 aa 21.3% 287 aa Compounds References
Gallus gallus Melatonin receptor 1B 289 aa 21.7% 267 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 20.5% 317 aa Compounds References
Rattus norvegicus Neuropeptide Y receptor type 1 382 aa 26.8% 310 aa Compounds References
Rattus norvegicus Trace amine-associated receptor 1 332 aa 23.3% 318 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 23.3% 317 aa Compounds References
Macaca fascicularis C-C chemokine receptor type 5 352 aa 25.1% 303 aa Compounds References
Macaca fascicularis B1 bradykinin receptor 352 aa 25.0% 284 aa Compounds References
Oryctolagus cuniculus C-X-C chemokine receptor type 2 358 aa 20.4% 324 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 23.5% 289 aa Compounds References
Rattus norvegicus Serotonin 5a (5-HT5a) receptor 357 aa 19.9% 332 aa Compounds References
Rattus norvegicus Adenosine A1 receptor 326 aa 20.7% 323 aa Compounds References
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 24.5% 318 aa Compounds References
Macaca mulatta Trace amine-associated receptor 1 338 aa 20.3% 320 aa Compounds References
Canis lupus familiaris Bradykinin B1 receptor 350 aa 25.5% 333 aa Compounds References
Carassius auratus Dopamine D1 receptor 363 aa 25.3% 300 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 23.0% 317 aa Compounds References
Macaca mulatta G-protein coupled receptor 81 337 aa 21.4% 331 aa Compounds References
Cavia porcellus Cysteinyl leukotriene receptor 1 340 aa 19.3% 311 aa Compounds References
Gallus gallus Melatonin receptor 346 aa 21.5% 307 aa Compounds References
Macaca fascicularis Melanin-concentrating hormone receptor 1 249 aa 23.2% 250 aa Compounds References
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) Human herpesvirus 5 chemokine receptor 354 aa 25.0% 324 aa Compounds References
Rattus norvegicus Galanin receptor 1 346 aa 25.2% 298 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 23.9% 318 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 19.9% 312 aa Compounds References
Rattus norvegicus Platelet activating factor receptor 341 aa 22.3% 278 aa Compounds References
Rattus norvegicus G protein-coupled receptor GPR35 306 aa 23.5% 285 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2573 (Onchocerca volvulus),
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