Detailed view for OVOC2490

Basic information

TDR Targets ID: 993390
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 8.7953 | Length (AA): 709 | MW (Da): 80034 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03942  

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130512)

Species Accession Gene Product
Brugia malayi Bm1_11820   hypothetical protein
Caenorhabditis elegans CELE_Y53C12A.10   Protein Y53C12A.10
Dictyostelium discoideum DDB_G0293222   hypothetical protein
Drosophila melanogaster Dmel_CG2006   CG2006 gene product from transcript CG2006-RA
Entamoeba histolytica EHI_023900   hypothetical protein, conserved
Entamoeba histolytica EHI_151860   hypothetical protein, conserved
Giardia lamblia GL50803_15898   hypothetical protein
Homo sapiens 56986   DTW domain containing 1
Leishmania braziliensis LbrM.34.1710   hypothetical protein, conserved
Leishmania donovani LdBPK_351790.1   DTW domain containing protein, putative
Leishmania infantum LinJ.35.1790   hypothetical protein, conserved
Leishmania major LmjF.35.1800   hypothetical protein, conserved
Leishmania mexicana LmxM.34.1800   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_14978   hypothetical protein
Loa Loa (eye worm) LOAG_05571   hypothetical protein
Mus musculus ENSMUSG00000023330   DTW domain containing 1
Neospora caninum NCLIV_059480   hypothetical protein, conserved
Onchocerca volvulus OVOC2490  
Trypanosoma brucei gambiense Tbg972.9.9300   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.15040   DTW domain containing protein, putative
Trypanosoma congolense TcIL3000_9_6260   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.509671.150   DTW domain containing protein, putative
Trypanosoma cruzi TcCLB.510763.90   DTW domain containing protein, putative
Toxoplasma gondii TGME49_216830   DTW domain-containing protein

Essentiality

OVOC2490 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.244.2810 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.244.2810 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.244.2810 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.244.2810 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_216830 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 38.5% 296 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 22.9% 297 aa Compounds References
Rattus norvegicus Jak1 protein 210 aa 25.1% 175 aa Compounds References
Xenopus laevis Aurora kinase B-A 361 aa 24.4% 344 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 26.3% 304 aa Compounds References
Schizosaccharomyces pombe 972h- Casein kinase II subunit alpha 332 aa 23.9% 297 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 32.3% 158 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 27.1% 303 aa Compounds References
Patiria pectinifera Cdc2 300 aa 26.5% 298 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 27.0% 289 aa Compounds References
Bos taurus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 40.1% 292 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 24.9% 273 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 25.2% 302 aa Compounds References
Rattus norvegicus cAMP-dependent protein kinase alpha-catalytic subunit 351 aa 39.4% 302 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier OVOC2490 (Onchocerca volvulus),
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