Detailed view for OVOC10517

Basic information

TDR Targets ID: 993642
Onchocerca volvulus,
Source Database / ID:  Wormbase Parasite  

pI: 6.0892 | Length (AA): 424 | MW (Da): 47725 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 146 5aei (A) 21 179 13.00 0.94 0.74 0.598122 -1.03
25 338 5mfm (A) 11 329 10.00 0.046 0.17 1.09552 -0.83
36 269 1xqr (A) 87 306 24.00 0 1 1.00852 -1.09
77 210 6mzg (E) 406 541 28.00 0.31 0.24 0.473262 0.58
103 197 4rv1 (A) 1 93 15.00 0 0.75 0.649892 -1.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130399)

Species Accession Gene Product
Arabidopsis thaliana AT5G02150   protein Fes1C
Arabidopsis thaliana AT3G09350   protein Fes1A
Babesia bovis BBOV_III004880   hypothetical protein
Brugia malayi Bm1_43295   hypothetical protein
Cryptosporidium hominis Chro.20225   hypothetical protein
Cryptosporidium parvum cgd2_2080   hypothetical protein
Drosophila melanogaster Dmel_CG10973   CG10973 gene product from transcript CG10973-RB
Echinococcus granulosus EgrG_000825450   hsp70 binding protein
Echinococcus multilocularis EmuJ_000825450   hsp70 binding protein
Homo sapiens ENSG00000133265   HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Loa Loa (eye worm) LOAG_03032   hypothetical protein
Mus musculus ENSMUSG00000063802   HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Neospora caninum NCLIV_033830   hypothetical protein
Oryza sativa 4332391   Os03g0271400
Oryza sativa 4334611   Os03g0822700
Onchocerca volvulus OVOC10517  
Plasmodium berghei PBANKA_1008000   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_0410600   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_0308700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_000720   hypothetical protein, conserved
Plasmodium yoelii PY02307   hypothetical protein
Toxoplasma gondii TGME49_273905   hypothetical protein
Theileria parva TP02_0461   hypothetical protein

Essentiality

OVOC10517 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_273905 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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