Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0697 | 0.4182 | 0.3568 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0697 | 0.4182 | 0.3568 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0373 | 0.0955 | 0.5 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0373 | 0.0955 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0697 | 0.4182 | 0.0702 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0373 | 0.0955 | 0.5 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0417 | 0.1394 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0417 | 0.1394 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0342 | 0.0644 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0373 | 0.0955 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0373 | 0.0955 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0373 | 0.0955 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0373 | 0.0955 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0373 | 0.0955 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0373 | 0.0955 | 0.0955 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0373 | 0.0955 | 0.5 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0373 | 0.0955 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0373 | 0.0955 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0417 | 0.1394 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0417 | 0.1394 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0373 | 0.0955 | 0.5 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0576 | 0.2975 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 134 uM | Inhibition of recombinant glucocerebrosidase in McIlvaine buffer at pH 5.2 after 10 mins by fluorometric analysis | ChEMBL. | 21370884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.