Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.5754 | 0.8425 |
Loa Loa (eye worm) | thymidylate synthase | 0.0115 | 0.1735 | 0.1735 |
Trichomonas vaginalis | glutaminase, putative | 0.03 | 0.6816 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.4881 | 0.4881 |
Loa Loa (eye worm) | glutaminase | 0.03 | 0.6816 | 0.6816 |
Brugia malayi | glutaminase DH11.1 | 0.03 | 0.6816 | 0.6816 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.6906 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.6906 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0115 | 0.1735 | 0.1674 |
Schistosoma mansoni | glutaminase | 0.03 | 0.6816 | 0.6147 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.6906 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0303 | 0.6906 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.6906 | 0.5 |
Loa Loa (eye worm) | glutaminase 2 | 0.03 | 0.6816 | 0.6816 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0303 | 0.6906 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.4881 | 0.4881 |
Brugia malayi | thymidylate synthase | 0.0115 | 0.1735 | 0.1735 |
Onchocerca volvulus | 0.0261 | 0.5754 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.4805 | 0.4766 |
Mycobacterium ulcerans | glutaminase | 0.03 | 0.6816 | 0.6147 |
Brugia malayi | hypothetical protein | 0.0055 | 0.0073 | 0.0073 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.