Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Rattus norvegicus | Epoxide hydrolase 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 2, subfamily C, polypeptide 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Loa Loa (eye worm) | cytochrome P450 family protein | Get druggable targets OG5_126582 | All targets in OG5_126582 |
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | cytochrome P450, family 2, subfamily C, polypeptide 8 | 490 aa | 435 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0395 | 0.8578 | 0.8578 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0125 | 0.1674 | 0.1674 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0329 | 0.6883 | 0.5 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0395 | 0.8578 | 0.8292 |
Brugia malayi | thymidylate synthase | 0.0125 | 0.1674 | 0.1674 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0329 | 0.6883 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0301 | 0.6179 | 0.541 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0329 | 0.6883 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0329 | 0.6883 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0329 | 0.6883 | 0.5 |
Onchocerca volvulus | 0.0125 | 0.1674 | 0.5 | |
Echinococcus granulosus | sodium channel protein | 0.0301 | 0.6179 | 0.541 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0329 | 0.6883 | 0.5 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0301 | 0.6179 | 0.541 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CLH (ADMET) | < 0.033 ml/min | Intrinsic clearance in human liver microsomes measured per mg of protein at 1 uM after 30 mins by LC/MS/MS analysis | ChEMBL. | 24530032 |
IC50 (binding) | = 3.3 nM | Inhibition of human recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay | ChEMBL. | 24530032 |
IC50 (binding) | = 6.6 nM | Inhibition of rat recombinant soluble epoxide hydrolase after 1 hr by fluorescence assay | ChEMBL. | 24530032 |
IC50 (ADMET) | = 0.8 uM | Inhibition of CYP2C8 in human liver microsomes after 10 mins by LC/MS/MS analysis | ChEMBL. | 24530032 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.