Detailed view for PF3D7_1321100

Basic information

TDR Targets ID: 20
Plasmodium falciparum, conserved Plasmodium protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.9908 | Length (AA): 3447 | MW (Da): 405102 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 16 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1155 2232 1epw (A) 230 1278 24.00 0.68 0.97 0.213936 1.7
1179 1427 1c1g (A) 12 273 20.00 0.19 0.01 0.186037 -0.16
1838 2020 3dls (A) 991 1189 17.00 0.047 0.22 -0.15471 0.95
1912 2006 3hko (A) 132 229 35.00 0.013 0.48 0.0797602 1.21
1917 3070 3v0a (B) 56 1162 17.00 0.00000016 0.73 0.199584 1.55
2347 2441 3ult (A) 17 107 34.00 0.0069 0.36 0.48076 -1.73
2401 2679 2fds (A) 6 323 26.00 0.87 0.85 0.11814 0.22
2663 3435 3s5h (A) 252 1043 23.00 0.062 0.89 0.129453 1.78
50 1032 4w8f (A) 1366 2437 10.00 0 0.75 -0.131857 1
221 878 5czz (A) 271 1006 22.00 0.11 0.83 0.136905 1.59
772 1813 1epw (A) 242 1278 23.00 0.094 1 0.257138 1.62
793 1240 4h5y (A) 161 586 23.00 0.25 0.59 0.185872 0.57
953 1068 2ap3 (A) 9 127 29.00 0.97 0.01 0.310733 -1.05
1942 2036 3ult (A) 17 107 34.00 0.0052 0.36 0.486829 -1.73
2045 2702 1pwu (A) 87 726 16.00 0.04 0.93 0.136105 1.1
2258 3030 3s5h (A) 252 1043 23.00 0.046 0.71 0.158709 1.63

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 40 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 48 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, Ring. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_161142)

Species Accession Gene Product
Plasmodium berghei PBANKA_1419400   conserved Plasmodium protein, unknown function
Plasmodium falciparum PF3D7_1321100   conserved Plasmodium protein, unknown function
Plasmodium knowlesi PKNH_1421700   conserved Plasmodium protein, unknown function
Plasmodium vivax PVX_122865   hypothetical protein, conserved
Plasmodium yoelii PY01630   protein with 5'-3' exonuclease domain
Plasmodium yoelii PY01631   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1321100 (Plasmodium falciparum), conserved Plasmodium protein, unknown function
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