Detailed view for Smp_162370

Basic information

TDR Targets ID: 282846
Schistosoma mansoni, Linker histone H1
Source Database / ID:  GeneDB

pI: 11.5829 | Length (AA): 169 | MW (Da): 18026 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00538   linker histone H1 and H5 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0000786   nucleosome  
GO:0003677   DNA binding  
GO:0006334   nucleosome assembly  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 100 2lso (A) 1 80 30.00 0 0.93 0.923507 -0.85
22 98 1hst (A) 24 97 49.00 0.00000023 0.85 0.888221 -0.19
22 98 1ghc (A) 2 75 47.00 0 1 0.947921 0.22
23 98 5nl0 (Z) 25 97 47.00 0.000000078 1 1.0963 -1.28
115 145 2n5n (A) 142 172 13.00 0 0 0.445732 -1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126767)

Species Accession Gene Product
Arabidopsis thaliana AT2G30620   histone H1.2
Arabidopsis thaliana AT1G06760   histone H1.1
Babesia bovis BBOV_II006290   hypothetical protein
Brugia malayi Bm1_02490   linker histone H1 and H5 family protein
Brugia malayi Bm1_04110   linker histone H1 and H5 family protein
Brugia malayi Bm1_04465   linker histone H1 and H5 family protein
Candida albicans CaO19_5137.5   hypothetical protein
Caenorhabditis elegans CELE_Y73B6BL.9   Protein HIL-2, isoform A
Caenorhabditis elegans CELE_F59A7.4   Protein HIL-6
Caenorhabditis elegans CELE_M163.3   Protein HIS-24
Caenorhabditis elegans CELE_C18G1.5   Protein HIL-4
Caenorhabditis elegans CELE_B0414.3   Protein HIL-5
Caenorhabditis elegans CELE_F22F1.1   Protein HIL-3
Dictyostelium discoideum DDB_G0285319   calmodulin-binding protein
Drosophila melanogaster Dmel_CG33831   CG33831 gene product from transcript CG33831-RA
Drosophila melanogaster Dmel_CG33816   CG33816 gene product from transcript CG33816-RA
Drosophila melanogaster Dmel_CG33828   CG33828 gene product from transcript CG33828-RA
Drosophila melanogaster Dmel_CG33834   CG33834 gene product from transcript CG33834-RA
Drosophila melanogaster Dmel_CG33840   CG33840 gene product from transcript CG33840-RA
Drosophila melanogaster Dmel_CG33864   CG33864 gene product from transcript CG33864-RA
Drosophila melanogaster Dmel_CG33852   CG33852 gene product from transcript CG33852-RA
Drosophila melanogaster Dmel_CG33855   CG33855 gene product from transcript CG33855-RA
Drosophila melanogaster Dmel_CG33822   CG33822 gene product from transcript CG33822-RA
Drosophila melanogaster Dmel_CG33807   CG33807 gene product from transcript CG33807-RA
Drosophila melanogaster Dmel_CG33837   CG33837 gene product from transcript CG33837-RA
Drosophila melanogaster Dmel_CG33849   CG33849 gene product from transcript CG33849-RA
Drosophila melanogaster Dmel_CG33861   CG33861 gene product from transcript CG33861-RA
Drosophila melanogaster Dmel_CG33819   CG33819 gene product from transcript CG33819-RA
Drosophila melanogaster Dmel_CG33825   CG33825 gene product from transcript CG33825-RA
Drosophila melanogaster Dmel_CG33843   CG33843 gene product from transcript CG33843-RA
Drosophila melanogaster Dmel_CG33813   CG33813 gene product from transcript CG33813-RA
Drosophila melanogaster Dmel_CG33810   CG33810 gene product from transcript CG33810-RA
Drosophila melanogaster Dmel_CG33801   CG33801 gene product from transcript CG33801-RA
Drosophila melanogaster Dmel_CG33804   CG33804 gene product from transcript CG33804-RA
Drosophila melanogaster Dmel_CG33858   CG33858 gene product from transcript CG33858-RA
Drosophila melanogaster Dmel_CG31617   CG31617 gene product from transcript CG31617-RA
Drosophila melanogaster Dmel_CG33846   CG33846 gene product from transcript CG33846-RA
Echinococcus granulosus EgrG_000906000   Histone H1 delta
Echinococcus granulosus EgrG_000499300   histone H1 gamma protein
Echinococcus granulosus EgrG_000499100   histone H1 gamma protein
Echinococcus multilocularis EmuJ_000499300   histone H1 gamma protein
Echinococcus multilocularis EmuJ_000906000   Histone H1 delta
Echinococcus multilocularis EmuJ_000499100   histone H1 gamma protein
Homo sapiens ENSG00000189060   H1 histone family, member 0
Homo sapiens ENSG00000184357   histone cluster 1, H1b
Loa Loa (eye worm) LOAG_06687   linker histone H1 and H5 family protein
Loa Loa (eye worm) LOAG_06950   linker histone H1 and H5 family protein
Mus musculus 50709   histone cluster 1, H1e
Mus musculus ENSMUSG00000058773   histone cluster 1, H1b
Mus musculus ENSMUSG00000096210   H1 histone family, member 0
Oryza sativa 4334439   Os03g0799000
Oryza sativa 4335314   Os04g0253000
Oryza sativa 4342583   Os07g0184800
Saccharomyces cerevisiae YPL127C   histone H1
Schistosoma japonicum Sjp_0000130   Histone H1-delta, putative
Schistosoma mansoni Smp_003770   histone h1/h5
Schistosoma mansoni Smp_162370   Linker histone H1
Schmidtea mediterranea mk4.004990.01   Histone H1
Schmidtea mediterranea mk4.018999.00   Linker histone H1
Schmidtea mediterranea mk4.006907.05   Linker histone H1
Schmidtea mediterranea mk4.017587.00   Linker histone H1
Schmidtea mediterranea mk4.018508.01   Linker histone H1
Schmidtea mediterranea mk4.014818.00   Linker histone H1

Essentiality

Smp_162370 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F59A7.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F59A7.4 Caenorhabditis elegans larval arrest wormbase
CELE_M163.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_M163.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens H1 histone family, member 0 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_162370 (Schistosoma mansoni), Linker histone H1
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