Detailed view for Smp_127370

Basic information

TDR Targets ID: 282971
Schistosoma mansoni, glycosyltransferase 14 family member
Source Database / ID:  GeneDB

pI: 9.4821 | Length (AA): 386 | MW (Da): 45894 | Paralog Number: 5

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02485   Core-2/I-Branching enzyme

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0008375   acetylglucosaminyltransferase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 380 6eje (A) 254 639 17.00 0 1 1.069 0.59
11 359 2gak (A) 46 423 29.00 0 1 1.20495 -0.61

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130811)

Species Accession Gene Product
Caenorhabditis elegans CELE_T15D6.3   Protein GLY-17
Caenorhabditis elegans CELE_F22D6.11   Protein GLY-18
Caenorhabditis elegans CELE_T15D6.2   Protein GLY-16
Caenorhabditis elegans CELE_F22D6.12   Protein GLY-19
Caenorhabditis elegans CELE_F44F4.6   Protein GLY-1
Caenorhabditis elegans CELE_C54C8.11   Protein GLY-15, isoform B
Echinococcus granulosus EgrG_000412000   glycosyltransferase 14 family member
Echinococcus granulosus EgrG_001119500   glycosyltransferase 14 family member
Echinococcus granulosus EgrG_000418600   beta 13 galactosyl O glycosyl glycoprotein
Echinococcus granulosus EgrG_000418900   glycosyltransferase 14 family member
Echinococcus granulosus EgrG_000024200   glycosyltransferase 14 family member
Echinococcus granulosus EgrG_001069500   beta 13 galactosyl O glycosyl glycoprotein
Echinococcus multilocularis EmuJ_000412000   glycosyltransferase 14 family member
Echinococcus multilocularis EmuJ_000024200   glycosyltransferase 14 family member
Echinococcus multilocularis EmuJ_000418600   beta 1,3 galactosyl O glycosyl glycoprotein
Echinococcus multilocularis EmuJ_000039600   beta 1,3 galactosyl O glycosyl glycoprotein
Echinococcus multilocularis EmuJ_000418900   glycosyltransferase 14 family member
Echinococcus multilocularis EmuJ_001069500   beta 1,3 galactosyl O glycosyl glycoprotein
Echinococcus multilocularis EmuJ_001119500   glycosyltransferase 14 family member
Homo sapiens ENSG00000140297   glucosaminyl (N-acetyl) transferase 3, mucin type
Homo sapiens ENSG00000187210   glucosaminyl (N-acetyl) transferase 1, core 2
Mus musculus ENSMUSG00000038843   glucosaminyl (N-acetyl) transferase 1, core 2
Mus musculus ENSMUSG00000032226   glucosaminyl (N-acetyl) transferase 3, mucin type
Schistosoma japonicum Sjp_0048330   Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, putative
Schistosoma japonicum Sjp_0048320   ko:K09662 N-acetylglucosaminyltransferase 3, mucin type, putative
Schistosoma japonicum Sjp_0108330   expressed protein
Schistosoma japonicum Sjp_0030170   Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, putative
Schistosoma japonicum Sjp_0030180   Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3, putative
Schistosoma japonicum Sjp_0104740   Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4, putative
Schistosoma japonicum Sjp_0087690   ko:K00742 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase [EC2.4.1.150], putative
Schistosoma japonicum Sjp_0314850   expressed protein
Schistosoma mansoni Smp_154680   glycosyltransferase 14 family member
Schistosoma mansoni Smp_127370   glycosyltransferase 14 family member
Schistosoma mansoni Smp_037720   hypothetical protein
Schistosoma mansoni Smp_009810   glycosyltransferase 14 family member
Schistosoma mansoni Smp_187360   glycosyltransferase 14 family member
Schistosoma mansoni Smp_154670   glycosyltransferase 14 family member
Schmidtea mediterranea mk4.003820.01  
Schmidtea mediterranea mk4.004352.01  
Schmidtea mediterranea mk4.001570.00  
Schmidtea mediterranea mk4.000742.04  
Schmidtea mediterranea mk4.001242.01  
Schmidtea mediterranea mk4.004613.02  
Schmidtea mediterranea mk4.009518.00  
Schmidtea mediterranea mk4.015678.00  
Schmidtea mediterranea mk4.004351.01  
Schmidtea mediterranea mk4.041086.00  
Schmidtea mediterranea mk4.003640.00  
Schmidtea mediterranea mk4.017575.00  
Schmidtea mediterranea mk4.044944.00  
Schmidtea mediterranea mk4.008764.00  
Schmidtea mediterranea mk4.007300.00  
Schmidtea mediterranea mk4.007394.00  
Schmidtea mediterranea mk4.022030.01  
Schmidtea mediterranea mk4.001277.03  
Schmidtea mediterranea mk4.003672.00  
Schmidtea mediterranea mk4.002327.03  
Schmidtea mediterranea mk4.009727.00  
Schmidtea mediterranea mk4.001277.00  
Schmidtea mediterranea mk4.011886.01  
Schmidtea mediterranea mk4.002782.00  
Schmidtea mediterranea mk4.025017.00  
Schmidtea mediterranea mk4.003820.00  
Schmidtea mediterranea mk4.033025.00  
Schmidtea mediterranea mk4.000120.12  
Schmidtea mediterranea mk4.001570.01  
Schmidtea mediterranea mk4.001242.02  
Schmidtea mediterranea mk4.001277.04  
Schmidtea mediterranea mk4.004351.00  
Schmidtea mediterranea mk4.004335.02  
Schmidtea mediterranea mk4.000016.10  
Schmidtea mediterranea mk4.004160.01  
Schmidtea mediterranea mk4.009727.01   Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 6

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_127370 (Schistosoma mansoni), glycosyltransferase 14 family member
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