pI: 5.3657 |
Length (AA): 488 |
MW (Da): 55451 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 79 | 1wx8 (A) | 16 | 92 | 26.00 | 0 | 0.88 | 0.641336 | -1.75 |
4 | 73 | 3plu (A) | 2 | 71 | 23.00 | 0 | 1 | 0.651943 | -2.07 |
18 | 73 | 5chw (A) | 17 | 72 | 41.00 | 0.00013 | 1 | 0.789154 | -1.77 |
111 | 473 | 2ayn (A) | 102 | 481 | 34.00 | 0 | 1 | 1.07835 | -0.16 |
112 | 488 | 1nb8 (A) | 213 | 532 | 24.00 | 0 | 1 | 0.811041 | 0.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127806)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G51710 | ubiquitin carboxyl-terminal hydrolase 6 |
Arabidopsis thaliana | AT3G21280 | ubiquitin-specific protease 7 |
Babesia bovis | BBOV_III008630 | ubiquitin carboxyl-terminal hydrolase family protein |
Brugia malayi | Bm1_28765 | ubiquitin specific protease 14 |
Brugia malayi | Bm1_56885 | Ubiquitin carboxyl-terminal hydrolase family protein |
Brugia malayi | Bm1_28760 | hypothetical protein |
Candida albicans | CaO19.6063 | ubiquitin-specific protease |
Candida albicans | CaO19.13484 | ubiquitin-specific protease |
Caenorhabditis elegans | CELE_C13B4.2 | Protein USP-14 |
Cryptosporidium hominis | Chro.10040 | tRNA-guaninine transglycosylase |
Cryptosporidium parvum | cgd1_290 | Ub6p like ubiquitin at N-terminus and ubiquitin C terminal hydrolase at the C-terminus |
Dictyostelium discoideum | DDB_G0271264 | peptidase C19 family protein |
Drosophila melanogaster | Dmel_CG5384 | CG5384 gene product from transcript CG5384-RB |
Echinococcus granulosus | EgrG_000580300 | ubiquitin carboxyl terminal hydrolase 14 |
Echinococcus multilocularis | EmuJ_000580300 | ubiquitin carboxyl terminal hydrolase 14 |
Giardia lamblia | GL50803_8189 | Ubiquitin carboxyl-terminal hydrolase 14 |
Homo sapiens | 9097 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
Leishmania braziliensis | LbrM.31.0140 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania donovani | LdBPK_310150.1 | ubiquitin carboxyl-terminal hydrolase, putative |
Leishmania infantum | LinJ.31.0150 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania major | LmjF.31.0140 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Leishmania mexicana | LmxM.30.0140 | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Loa Loa (eye worm) | LOAG_02396 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02397 | hypothetical protein |
Mus musculus | ENSMUSG00000047879 | ubiquitin specific peptidase 14 |
Neospora caninum | NCLIV_055070 | Ubiquitin carboxyl-terminal hydrolase (EC 3.1.2.15), related |
Oryza sativa | 4326194 | Os01g0550100 |
Plasmodium berghei | PBANKA_1242000 | ubiquitin carboxyl-terminal hydrolase 14, putative |
Plasmodium falciparum | PF3D7_0527200 | ubiquitin carboxyl-terminal hydrolase 14 |
Plasmodium knowlesi | PKNH_1005500 | ubiquitin carboxyl-terminal hydrolase 14, putative |
Plasmodium vivax | PVX_079880 | ubiquitin carboxyl-terminal hydrolase, putative |
Plasmodium yoelii | PY03738 | tRNA-guaninine transglycosylase, putative, putative |
Saccharomyces cerevisiae | YFR010W | Ubp6p |
Schistosoma japonicum | Sjp_0209980 | ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative |
Schistosoma japonicum | Sjp_0209970 | ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative |
Schistosoma mansoni | Smp_084740 | ubiquitin-specific peptidase 14 (C19 family) |
Schmidtea mediterranea | mk4.009566.00 | Ubiquitin carboxyl-terminal hydrolase 14 |
Trypanosoma brucei gambiense | Tbg972.4.3850 | ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative |
Trypanosoma brucei | Tb927.4.3790 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma congolense | TcIL3000_0_29070 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma congolense | TcIL3000_4_3320 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma congolense | TcIL3000_0_32960 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma cruzi | TcCLB.504443.10 | ubiquitin carboxyl-terminal hydrolase, putative |
Trypanosoma cruzi | TcCLB.506569.10 | ubiquitin carboxyl-terminal hydrolase, putative |
Toxoplasma gondii | TGME49_311090 | ubiquitin carboxyl-terminal hydrolase |
Theileria parva | TP04_0767 | ubiquitin carboxyl-terminal hydrolase, putative |
Trichomonas vaginalis | TVAG_296140 | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.3790 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.3790 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.3790 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.3790 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
PBANKA_1242000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_311090 | Toxoplasma gondii | Essentiality uncertain | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | Compounds | References |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | Compounds | References |