pI: 6.3365 |
Length (AA): 244 |
MW (Da): 28100 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
98 | 225 | 2kva (A) | 610 | 724 | 17.00 | 0 | 0.49 | 0.59389 | 0.07 |
101 | 226 | 3aih (A) | 110 | 229 | 32.00 | 0 | 0.64 | 0.586993 | 0.89 |
130 | 226 | 4xqm (A) | 357 | 450 | 17.00 | 0.00000095 | 0.07 | 0.539141 | -0.09 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_130682)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_14990 | CG6766-PA |
Candida albicans | CaO19.7578 | weak similarity to S. cerevisiae YOS9 (YDR057W) involved in transport of GPI-anchored proteins to the Golgi apparatus. |
Caenorhabditis elegans | CELE_Y105E8A.2 | Protein Y105E8A.2 |
Dictyostelium discoideum | DDB_G0275851 | OS-9-related protein |
Drosophila melanogaster | Dmel_CG6766 | CG6766 gene product from transcript CG6766-RA |
Echinococcus granulosus | EgrG_000851000 | XTP3 transactivated gene B protein |
Echinococcus multilocularis | EmuJ_000851000 | XTP3 transactivated gene B protein |
Homo sapiens | ENSG00000068912 | endoplasmic reticulum lectin 1 |
Loa Loa (eye worm) | LOAG_03813 | hypothetical protein |
Mus musculus | 66753 | endoplasmic reticulum lectin 1 |
Onchocerca volvulus | OVOC1226 | Endoplasmic reticulum lectin 1 homolog |
Saccharomyces cerevisiae | YDR057W | Yos9p |
Schistosoma japonicum | Sjp_0091010 | IPR009011,Mannose-6-phosphate receptor, binding,domain-containing |
Schistosoma japonicum | Sjp_0079540 | XTP3-transactivated gene B protein homolog precursor, putative |
Schistosoma mansoni | Smp_149050.2 | xtp3-transactivated protein B |
Schistosoma mansoni | Smp_149050.1 | xtp3-transactivated protein B |
Schmidtea mediterranea | mk4.001012.03 | Endoplasmic reticulum lectin 1 |
Schmidtea mediterranea | mk4.001012.01 | Endoplasmic reticulum lectin 1 |
Trypanosoma brucei gambiense | Tbg972.11.11990 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000.11.11360 | glucosidase II beta subunit-like protein, putative |
Trypanosoma congolense | TcIL3000_0_10380 | glucosidase II beta subunit-like protein, putative |
Trypanosoma cruzi | TcCLB.506155.99 | hypothetical protein, conserved |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.