pI: 9.6889 |
Length (AA): 167 |
MW (Da): 19545 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 32 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Female Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Ring, Sporozoite, Male Gametocyte. | Zanghi G Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Ortholog group members (OG5_142475)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_II007570 | hypothetical protein |
Neospora caninum | NCLIV_058550 | hypothetical protein, conserved |
Plasmodium berghei | PBANKA_0203750 | phosphatidate cytidylyltransferase, putative |
Plasmodium berghei | PBANKA_0203650 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0109850 | phosphatidate cytidylyltransferase, putative |
Plasmodium falciparum | PF3D7_0109950 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0203950 | phosphatidate cytidylyltransferase, putative |
Plasmodium knowlesi | PKNH_0203850 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_081294 | conserved Plasmodium protein, unknown function |
Plasmodium vivax | PVX_081296 | phosphatidate cytidylyltransferase, putative |
Toxoplasma gondii | TGME49_315930 | integral membrane protein, DUF56 family protein, putative |
Theileria parva | TP02_0702 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_0203650 | Plasmodium berghei | Essential | plasmo |
PBANKA_0203750 | Plasmodium berghei | Essential | plasmo |
TGME49_315930 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.