Detailed view for PF3D7_0621350

Basic information

TDR Targets ID: 829728
Plasmodium falciparum, protein SYS1, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.8093 | Length (AA): 138 | MW (Da): 16490 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09801   Integral membrane protein S linking to the trans Golgi network

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 16 hs, Female Gametocyte. Otto TD Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Oocyst, Sporozoite, Male Gametocyte. Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Ring. Otto TD Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_129756)

Species Accession Gene Product
Brugia malayi Bm1_36185   Hypothetical 23.7 kDa protein in CYR1-OST1 intergenic region
Candida albicans CaO19_7128   hypothetical protein
Candida albicans CaO19.7128   similar to mammalian SPC12
Caenorhabditis elegans CELE_T03F1.12   Protein T03F1.12
Dictyostelium discoideum DDB_G0269368   hypothetical protein
Drosophila melanogaster Dmel_CG11753   CG11753 gene product from transcript CG11753-RC
Echinococcus granulosus EgrG_000464000   protein sys1
Echinococcus multilocularis EmuJ_000464000   protein sys1
Homo sapiens ENSG00000204070   Sys1 golgi trafficking protein
Loa Loa (eye worm) LOAG_02701   hypothetical protein
Mus musculus ENSMUSG00000045503   SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
Neospora caninum NCLIV_047210   hypothetical protein, conserved
Oryza sativa 4326384   Os01g0593600
Onchocerca volvulus OVOC539  
Plasmodium falciparum PF3D7_0621350   protein SYS1, putative
Saccharomyces cerevisiae YJL004C   Sys1p
Schistosoma japonicum Sjp_0014570   Protein SYS1 homolog, putative
Schistosoma mansoni Smp_038410   hypothetical protein
Schmidtea mediterranea mk4.000994.00   Protein SYS1 homolog
Toxoplasma gondii TGME49_225500   hypothetical protein
Trichomonas vaginalis TVAG_266030   conserved hypothetical protein

Essentiality

PF3D7_0621350 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_225500 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_0621350 (Plasmodium falciparum), protein SYS1, putative
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