Identification and ranking of targets against neglected tropical diseases
TDR Targets ID: 9991 Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) Source Database / ID: TubercuList / Rv0013
pI: 6.5 | Length (AA): 232 | MW (Da): 24627 | Number of Paralogs: 1 | | EC number: 4.1.3.27
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00117 GATase
Biological Process: GO:0009058 biosynthetic process [+/–] show term definition The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes. GO:0006541 glutamine metabolic process [+/–] show term definition The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0008152 metabolic process [+/–] show term definition Processes that cause many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes.
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
Processes that cause many of the chemical changes in living organisms, including anabolism and catabolism. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
Molecular Function: GO:0003824 catalytic activity [+/–] show term definition Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology GO:0004049 anthranilate synthase activity [+/–] show term definition Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Folate biosynthesis (KEGG)
No functional classes assigned to this gene.
Modbase 3D models: Rv0013
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 8 Cumulative epitope score: 9.1 Normalized epitope score: 3.9 Percentile: 17.4 (this protein belongs to the top 82.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL cluster: OG1.2_2967 Number of Paralogs: 1 Arabidopsis thaliana At1g24909.1 | OrthoMCL Arabidopsis thaliana At5g57890.1 | OrthoMCL Arabidopsis thaliana At1g25155.1 | OrthoMCL Arabidopsis thaliana At1g25083.1 | OrthoMCL Arabidopsis thaliana At1g25220.1 | OrthoMCL Arabidopsis thaliana At1g24807.1 | OrthoMCL Escherichia coli K12 gi|16131239|ref|NP_417819.1| | OrthoMCL Mycobacterium leprae strain TN ML0015 | OrthoMCL Mycobacterium tuberculosis Rv0013 (this record). | OrthoMCL Saccharomyces cerevisiae YKL211C | OrthoMCL
[+/–] Show essentiality data references.
No manually curated information for this target.
Mean compound desirability (max is 1): Mean number of compounds:
Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.
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1 chemical compound is associated with this gene.
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Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
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Gene identifier: Rv0013 Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)
1 literature reference was collected for this gene.
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