Detailed view for Rv0013

Basic information

TDR Targets ID: 9991
Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)

Source Database / ID: TubercuList / Rv0013

pI: 6.5 | Length (AA): 232 | MW (Da): 24627 | Number of Paralogs: 1 | | EC number: 4.1.3.27

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00117   GATase

Gene Ontology

Biological Process:
GO:0009058   biosynthetic process   [+/–] show term definition

The energy-requiring part of metabolism in which simpler substances are transformed into more complex ones, as in growth and other biosynthetic processes.

GO:0006541   glutamine metabolic process   [+/–] show term definition
GO:0008152   metabolic process   [+/–] show term definition

Molecular Function:
GO:0003824   catalytic activity   [+/–] show term definition

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology

GO:0004049   anthranilate synthase activity   [+/–] show term definition

Metabolic Pathways

Folate biosynthesis (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0013  

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 8
Cumulative epitope score: 9.1
Normalized epitope score: 3.9
Percentile: 17.4 (this protein belongs to the top 82.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_2967
Number of Paralogs: 1
Arabidopsis thaliana At1g24909.1   |   OrthoMCL
Arabidopsis thaliana At5g57890.1   |   OrthoMCL
Arabidopsis thaliana At1g25155.1   |   OrthoMCL
Arabidopsis thaliana At1g25083.1   |   OrthoMCL
Arabidopsis thaliana At1g25220.1   |   OrthoMCL
Arabidopsis thaliana At1g24807.1   |   OrthoMCL
Escherichia coli K12 gi|16131239|ref|NP_417819.1|   |   OrthoMCL
Mycobacterium leprae strain TN ML0015   |   OrthoMCL
Mycobacterium tuberculosis Rv0013 (this record).   |   OrthoMCL
Saccharomyces cerevisiae YKL211C   |   OrthoMCL

Essentiality Rv0013 has essentiality data
Gene/Ortholog: eco3242 (OG1.2_2967); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco3242 (OG1.2_2967); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3242 (OG1.2_2967); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3242 (OG1.2_2967); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Mean compound desirability (max is 1):
Mean number of compounds:

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

1 chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic references

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or contact us.

User comments

No user comments are available for this gene.

Log in to add comments, or register.