Detailed view for Rv0013

Basic information

TDR Targets ID: 9991
Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)

Source Database / ID: Tuberculist / Rv0013 

pI: 6.5 | Length (AA): 232 | MW (Da): 24627 | Number of Paralogs: 0

EC number(s): 2.6.1.85 | Enzyme, KEGG, Brenda (mouse over to display more information)
4.1.3.27 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00117   GATase

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003824   catalytic activity  
GO:0004049   anthranilate synthase activity  

Process: (mouse over links to read term descriptions)

GO:0009058   biosynthetic process  
GO:0008152   metabolic process  
GO:0006541   glutamine metabolic process  
Metabolic Pathways

Folate biosynthesis (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0013  

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 8
Cumulative epitope score: 9.1
Normalized epitope score: 3.9
Percentile: 17.4 (this protein belongs to the top 82.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_11989
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_173893   ASB1 (ANTHRANILATE SYNTHASE BETA SUBUNIT 1); anthranilate s... |   OrthoMCL
Arabidopsis thaliana NP_564224   anthranilate synthase beta subunit, putative ... |   OrthoMCL
Arabidopsis thaliana NP_173885   anthranilate synthase beta subunit, putative ... |   OrthoMCL
Arabidopsis thaliana NP_173875   anthranilate synthase beta subunit, putative ... |   OrthoMCL
Arabidopsis thaliana NP_200597   anthranilate synthase beta subunit, putative ... |   OrthoMCL
Arabidopsis thaliana NP_564225   anthranilate synthase beta subunit, putative ... |   OrthoMCL
Cryptosporidium neoformas XP_572795   anthranilate synthase ... |   OrthoMCL
Escherichia coli K12 NP_417819.1   para-aminobenzoate synthase component II [Escherichia coli K... |   OrthoMCL
Mycobacterium leprae strain TN ML0015   Possible anthranilate synthase component II TrpG (glutamine ... |   OrthoMCL
Mycobacterium tuberculosis Rv0013 (this record).   POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE ... |   OrthoMCL
Neospora caninum NCLIV_022000   para-aminobenzoate synthase, putative... |   OrthoMCL
Oryza sativa NP_001051085   Os03g0718000 ... |   OrthoMCL
Oryza sativa NP_001053011   Os04g0463500 ... |   OrthoMCL
Saccharomyces cerevisiae YKL211C   TRP3 SGDID:S000001694, Chr XI from 38154-36700, reverse comp... |   OrthoMCL

Essentiality Rv0013 has essentiality data
Gene/Ortholog: eco3242 (OG4_11989); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco3242 (OG4_11989); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3242 (OG4_11989); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3242 (OG4_11989); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds is associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    1 literature reference was collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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