A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 9991 Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) Source Database / ID: Tuberculist / Rv0013
pI: 6.5 | Length (AA): 232 | MW (Da): 24627 | Number of Paralogs: 0
EC number(s): 2.6.1.85 | Enzyme, KEGG, Brenda (mouse over to display more information) 4.1.3.27 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0
[DGPI v2.04]
PF00117 GATase
Function: (mouse over links to read term descriptions)
Process: (mouse over links to read term descriptions)
Folate biosynthesis (KEGG)
No functional classes assigned to this gene.
Modbase 3D models: Rv0013
PDB structures: no structure available for this protein in the PDB.
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 8 Cumulative epitope score: 9.1 Normalized epitope score: 3.9 Percentile: 17.4 (this protein belongs to the top 82.6% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_11989 Number of Paralogs: 0
Ortholog group members from selected species: Arabidopsis thaliana NP_173893 ASB1 (ANTHRANILATE SYNTHASE BETA SUBUNIT 1); anthranilate s... | OrthoMCL Arabidopsis thaliana NP_564224 anthranilate synthase beta subunit, putative ... | OrthoMCL Arabidopsis thaliana NP_173885 anthranilate synthase beta subunit, putative ... | OrthoMCL Arabidopsis thaliana NP_173875 anthranilate synthase beta subunit, putative ... | OrthoMCL Arabidopsis thaliana NP_200597 anthranilate synthase beta subunit, putative ... | OrthoMCL Arabidopsis thaliana NP_564225 anthranilate synthase beta subunit, putative ... | OrthoMCL Cryptosporidium neoformas XP_572795 anthranilate synthase ... | OrthoMCL Escherichia coli K12 NP_417819.1 para-aminobenzoate synthase component II [Escherichia coli K... | OrthoMCL Mycobacterium leprae strain TN ML0015 Possible anthranilate synthase component II TrpG (glutamine ... | OrthoMCL Mycobacterium tuberculosis Rv0013 (this record). POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE ... | OrthoMCL Neospora caninum NCLIV_022000 para-aminobenzoate synthase, putative... | OrthoMCL Oryza sativa NP_001051085 Os03g0718000 ... | OrthoMCL Oryza sativa NP_001053011 Os04g0463500 ... | OrthoMCL Saccharomyces cerevisiae YKL211C TRP3 SGDID:S000001694, Chr XI from 38154-36700, reverse comp... | OrthoMCL
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We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
User: ()
Gene identifier: Rv0013 Mycobacterium tuberculosis, POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE)
1 literature reference was collected for this gene.
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