Identification and ranking of targets against neglected tropical diseases
TDR Targets ID: 6945 Mycobacterium tuberculosis, POSSIBLE SERINE/THREONINE PHOSPHATASE PSTP Source Database / ID: TubercuList / Rv0018c
pI: 4.84 | Length (AA): 514 | MW (Da): 53780 | Number of Paralogs: 1 | | EC number: 3.1.3.16
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1
[DGPI v2.04]
PF00481 PP2C
Molecular Function: GO:0003824 catalytic activity [+/–] show term definition Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: Rv0018c
PDB structures: 1TXO 2CM1 2JFR 2JFS 2JFT
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 30 Cumulative epitope score: 33.2 Normalized epitope score: 6.5 Percentile: 97.7 (this protein belongs to the top 2.3% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL cluster: OG1.2_13114 Number of Paralogs: 1 Mycobacterium leprae strain TN ML0020 | OrthoMCL Mycobacterium tuberculosis Rv0018c (this record). | OrthoMCL
[+/–] Show essentiality data references.
No manually curated information for this target.
Druggability index (max is 1): 0.2 Mean compound desirability (max is 1): Mean number of compounds:
Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.
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1 chemical compound is associated with this gene.
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Assay information
Assay: Assay for Calcineurin (3.1.3.16 ); Source: Sigma-Aldrich Description: Automatic link to known assays based on EC numbers.
Reagent availability
Reagent: Rv0018c; Type: cloned gene; Source: BRENDA Notes: A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 );
User: ()
Gene identifier: Rv0018c Mycobacterium tuberculosis, POSSIBLE SERINE/THREONINE PHOSPHATASE PSTP
11 literature references were collected for this gene.
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