A chemogenomics resource for neglected tropical diseases
TDR Targets ID: 6945 Mycobacterium tuberculosis, PHOSPHOSERINE/THREONINE PHOSPHATASE PSTP Source Database / ID: Tuberculist / Rv0018c
pI: 4.8403 | Length (AA): 515 | MW (Da): 53780 | Number of Paralogs: 0
EC number(s): 3.1.3.16 | Enzyme, KEGG, Brenda (mouse over to display more information)
Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1
[DGPI v2.04]
PF00481 PP2C
Function: (mouse over links to read term descriptions)
This gene is not mapped to any metabolic pathway in KEGG.
No functional classes assigned to this gene.
Modbase 3D models: Rv0018c
PDB structures: 1TXO 2CM1 2JFR 2JFS 2JFT
Upregulation ranking: this gene ranks in the lower 0-20% group of genes. Shows this level of upregulation in: Dormant phase, Dormant phase.
References murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.. hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..
Number of putative antigenic epitopes: 30 Cumulative epitope score: 33.2 Normalized epitope score: 6.5 Percentile: 97.7 (this protein belongs to the top 2.3% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).
[+/–] More information on this prediction ...
Putative antigenic peptides were predicted using the method of Kolaskar and Tongaonkar, as implemented in EMBOSS (antigenic). Each predicted epitope has an associated score based on the physicochemical properties of the aminoacid residues. A cumulative antigenicity score was calculated as the sum of scores of all predicted epitopes in the protein. A normalized antigenicity index was calculated as the ratio of this cumulative score over the protein length. Finally, for each of these normalized antigenicity index values we calculated the percent of proteins for each genome that fall below it. Thus a protein with an antigenicity index percentile of 80 means that 80% of the proteins of the genome have a lower normalized antigenicity index score (i.e. this protein is amongst the top 20% of the proteins in these genome in terms of predicted antigenicity).
OrthoMCL 4 cluster: OG4_16401 Number of Paralogs: 0
Ortholog group members from selected species: Homo sapiens ENSP00000295908 | OrthoMCL Mycobacterium leprae strain TN ML0020c Possible serine/threonine phosphatase PstP... | OrthoMCL Mus musculus ENSMUSP00000041395 | OrthoMCL Mycobacterium tuberculosis Rv0018c (this record). PHOSPHOSERINE/THREONINE PHOSPHATASE PSTP... | OrthoMCL Oryza sativa NP_001046461 Os02g0255100 ... | OrthoMCL
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We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
Druggability index (range: 0 to 1): 0.2
Curated from literature
No chemical compounds is associated to this gene
Predicted associations
By orthology to known druggable targets
By sequence similarity to non orthologous druggable targets
Assay information
Assay: Assay for Calcineurin (3.1.3.16 ); Source: Sigma-Aldrich Description: Automatic link to known assays based on EC numbers.
Reagent availability
Reagent: Rv0018c; Type: cloned gene; Source: BRENDA Notes: A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 );
User: ()
Gene identifier: Rv0018c Mycobacterium tuberculosis, PHOSPHOSERINE/THREONINE PHOSPHATASE PSTP
11 literature references were collected for this gene.
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