Detailed view for Rv0018c

Basic information

TDR Targets ID: 6945
Mycobacterium tuberculosis, POSSIBLE SERINE/THREONINE PHOSPHATASE PSTP

Source Database / ID: TubercuList / Rv0018c

pI: 4.84 | Length (AA): 514 | MW (Da): 53780 | Number of Paralogs: 1 | | EC number: 3.1.3.16

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 1

Pfam domains

PF00481   PP2C

Gene Ontology

Molecular Function:
GO:0003824   catalytic activity   [+/–] show term definition

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Functional classes

No functional classes assigned to this gene.

Structural information

Modbase 3D models: Rv0018c  

PDB structures: 1TXO   2CM1   2JFR   2JFS   2JFT  

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 30
Cumulative epitope score: 33.2
Normalized epitope score: 6.5
Percentile: 97.7 (this protein belongs to the top 2.3% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_13114
Number of Paralogs: 1
Mycobacterium leprae strain TN ML0020   |   OrthoMCL
Mycobacterium tuberculosis Rv0018c (this record).   |   OrthoMCL

Essentiality Rv0018c has essentiality data
Gene/Ortholog: mtu18 (OG1.2_13114); Phenotype: non-essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Druggability index (max is 1): 0.2
Mean compound desirability (max is 1):
Mean number of compounds:

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

1 chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

Assay: Assay for Calcineurin (3.1.3.16 ); Source: Sigma-Aldrich
Description: Automatic link to known assays based on EC numbers.

Reagent availability

Reagent: Rv0018c; Type: cloned gene; Source: BRENDA
Notes: A gene with this EC number or name or sequence has been cloned from Mycobacterium tuberculosis ( 1 );

Bibliographic references

11 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or contact us.

User comments

No user comments are available for this gene.

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