pI: 4.2726 |
Length (AA): 502 |
MW (Da): 53055 |
Paralog Number:
31
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 83 | 5xfs (A) | 8 | 83 | 49.00 | 0 | 0.46 | 0.575094 | 0.82 |
139 | 355 | 3aja (A) | 74 | 317 | 16.00 | 0 | 0.37 | 0.424971 | -0.16 |
139 | 331 | 1g66 (A) | 3 | 196 | 19.00 | 0 | 0.14 | 0.238162 | 0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Dormant phase. | hasan |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_132981)
Species | Accession | Gene Product |
---|---|---|
Mycobacterium leprae | ML1183c | PE FAMILY PROTEIN |
Mycobacterium leprae | ML1053 | PE FAMILY PROTEIN |
Mycobacterium tuberculosis | Rv0977 | PE-PGRS family protein PE_PGRS16 |
Mycobacterium tuberculosis | Rv1651c | PE-PGRS family protein PE_PGRS30 |
Mycobacterium tuberculosis | Rv1169c | PE family protein. Possible lipase LipX. |
Mycobacterium tuberculosis | Rv3652 | PE-PGRS family-related protein PE_PGRS60 |
Mycobacterium tuberculosis | Rv0151c | PE family protein PE1 |
Mycobacterium tuberculosis | Rv1172c | PE family protein PE12 |
Mycobacterium tuberculosis | Rv1430 | PE family protein PE16 |
Mycobacterium tuberculosis | Rv1646 | PE family protein PE17 |
Mycobacterium tuberculosis | Rv1788 | PE family protein PE18 |
Mycobacterium tuberculosis | Rv1791 | PE family protein PE19 |
Mycobacterium tuberculosis | Rv0152c | PE family protein PE2 |
Mycobacterium tuberculosis | Rv1806 | PE family protein PE20 |
Mycobacterium tuberculosis | Rv1195 | PE family protein PE13 |
Mycobacterium tuberculosis | Rv2328 | PE family protein PE23 |
Mycobacterium tuberculosis | Rv2431c | PE family protein PE25 |
Mycobacterium tuberculosis | Rv2769c | PE family protein PE27 |
Mycobacterium tuberculosis | Rv0159c | PE family protein PE3 |
Mycobacterium tuberculosis | Rv3622c | PE family protein PE32 |
Mycobacterium tuberculosis | Rv1214c | PE family protein PE14 |
Mycobacterium tuberculosis | Rv0160c | PE family protein PE4 |
Mycobacterium tuberculosis | Rv0916c | PE family protein PE7 |
Mycobacterium tuberculosis | Rv1040c | PE family protein PE8 |
Mycobacterium tuberculosis | Rv1088 | PE family protein PE9 |
Mycobacterium tuberculosis | Rv3650 | PE family protein PE33 |
Mycobacterium tuberculosis | Rv2408 | Possible PE family-related protein PE24 |
Mycobacterium tuberculosis | Rv0832 | PE-PGRS family protein PE_PGRS12 |
Mycobacterium tuberculosis | Rv0335c | PE family protein PE6 |
Mycobacterium tuberculosis | Rv2519 | PE family protein PE26 |
Mycobacterium tuberculosis | Rv1800 | PPE family protein PPE28 |
Mycobacterium tuberculosis | Rv3812 | PE-PGRS family protein PE_PGRS62 |
Mycobacterium tuberculosis | Rv2608 | PPE family protein PPE42 |
Mycobacterium tuberculosis | Rv3477 | PE family protein PE31 |
Mycobacterium ulcerans | MUL_1450 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1034 | PE family protein |
Mycobacterium ulcerans | MUL_3990 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_2485 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3671 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_2783 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3088 | PE family protein |
Mycobacterium ulcerans | MUL_2354 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0740 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4909 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4620 | PE family protein |
Mycobacterium ulcerans | MUL_2250 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3084 | PE family protein |
Mycobacterium ulcerans | MUL_1149 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4381 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3741 | N-term PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0212 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1721 | PE PGRS family protein |
Mycobacterium ulcerans | MUL_0569 | PE PGRS family protein |
Mycobacterium ulcerans | MUL_3318 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1145 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4419 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3507 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4462 | PE family protein |
Mycobacterium ulcerans | MUL_4399 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0190 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_2440 | PPE family protein |
Mycobacterium ulcerans | MUL_0355 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3292 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3672 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4196 | PE family protein |
Mycobacterium ulcerans | MUL_4581 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4280 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1155 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0967 | PE family protein |
Mycobacterium ulcerans | MUL_2853 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1640 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1718 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1632 | PE family protein |
Mycobacterium ulcerans | MUL_3056 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3186 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1837 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4400 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1838 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1019 | PE family protein |
Mycobacterium ulcerans | MUL_0946 | PPE family protein |
Mycobacterium ulcerans | MUL_1339 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3062 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0570 | PE PGRS family protein |
Mycobacterium ulcerans | MUL_0572 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4489 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4524 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3704 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3247 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_4431 | PE-PGRS family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu992 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1680 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu152 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1453 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1675 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1819 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu153 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2368 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2473 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2816 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu160 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu161 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1106 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2653 | Mycobacterium tuberculosis | non-essential | nmpdr |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.