Detailed view for Rv0337c

Basic information

TDR Targets ID: 981316
Mycobacterium tuberculosis, Probable aspartate aminotransferase AspC (transaminase A) (ASPAT)
Source Database / ID:  Tuberculist 

pI: 4.9307 | Length (AA): 429 | MW (Da): 47318 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00155  

Gene Ontology

Mouse over links to read term descriptions.
GO:0030170   pyridoxal phosphate binding  
GO:0003824   catalytic activity  
GO:0009058   biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 429 4cvq (A) 1 404 59.00 0 1 1.72626 -1.01
126 227 3mad (A) 165 269 19.00 0.5 0.97 0.506962 -1.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127112)

Species Accession Gene Product
Arabidopsis thaliana AT1G72330   alanine aminotransferase 2
Arabidopsis thaliana AT1G17290   alanine aminotransferase
Arabidopsis thaliana AT1G23310   glutamate:glyoxylate aminotransferase
Arabidopsis thaliana AT1G70580   glutamate--glyoxylate aminotransferase 2
Candida albicans CaO19.346   putative alanine aminotransferase
Candida albicans CaO19.7979   putative alanine aminotransferase
Caenorhabditis elegans CELE_C32F10.8   Protein C32F10.8, isoform B
Dictyostelium discoideum DDB_G0285899   alanine aminotransferase
Drosophila melanogaster Dmel_CG1640   CG1640 gene product from transcript CG1640-RB
Escherichia coli b2290   valine-pyruvate aminotransferase 2
Echinococcus granulosus EgrG_000317500   alanine aminotransferase 2
Entamoeba histolytica EHI_159710   alanine aminotransferase, putative
Echinococcus multilocularis EmuJ_000317500   alanine aminotransferase 2
Giardia lamblia GL50803_12150   Alanine aminotransferase, putative
Giardia lamblia GL50803_16363   Alanine aminotransferase, putative
Homo sapiens ENSG00000167701   glutamic-pyruvate transaminase (alanine aminotransferase)
Homo sapiens ENSG00000166123   glutamic pyruvate transaminase (alanine aminotransferase) 2
Leishmania braziliensis LbrM.12.0630   alanine aminotransferase
Leishmania donovani LdBPK_120580.1   alanine aminotransferase, putative
Leishmania infantum LinJ.12.0580   alanine aminotransferase
Leishmania major LmjF.12.0630   alanine aminotransferase
Leishmania mexicana LmxM.12.0630   alanine aminotransferase, putative
Loa Loa (eye worm) LOAG_14583   hypothetical protein
Loa Loa (eye worm) LOAG_13624   hypothetical protein
Loa Loa (eye worm) LOAG_14412   hypothetical protein
Mycobacterium leprae ML2502   PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT)
Mus musculus ENSMUSG00000022546   glutamic pyruvic transaminase, soluble
Mus musculus ENSMUSG00000031700   glutamic pyruvate transaminase (alanine aminotransferase) 2
Mycobacterium tuberculosis Rv0337c   Probable aspartate aminotransferase AspC (transaminase A) (ASPAT)
Mycobacterium ulcerans MUL_0573   aminotransferase AlaT
Neospora caninum NCLIV_024040   Aminotransferase (EC 2.6.1.-), related
Oryza sativa 4347138   Os09g0433900
Oryza sativa 4348524   Os10g0390500
Oryza sativa 4342210   Os07g0108300
Oryza sativa 4343916   Os07g0617800
Onchocerca volvulus OVOC1454  
Saccharomyces cerevisiae YLR089C   alanine transaminase ALT1
Saccharomyces cerevisiae YDR111C   alanine transaminase ALT2
Schistosoma japonicum Sjp_0018880   ko:K00814 alanine transaminase [EC2.6.1.2], putative
Schistosoma japonicum Sjp_0308320   Alanine aminotransferase 2, putative
Schistosoma mansoni Smp_007760   alanine aminotransferase
Schmidtea mediterranea mk4.002901.04   Alanine aminotransferase, putative
Schmidtea mediterranea mk4.002317.00   Alanine aminotransferase, putative
Schmidtea mediterranea mk4.044997.00   Tyrosine aminotransferase
Schmidtea mediterranea mk4.001571.05   Alanine aminotransferase, putative
Trypanosoma brucei gambiense Tbg972.1.2510   alanine aminotransferase, putative
Trypanosoma brucei Tb927.1.3950   alanine aminotransferase
Trypanosoma congolense TcIL3000_1_1620   alanine aminotransferase, putative
Trypanosoma cruzi TcCLB.510889.120   glutamic--pyruvic transaminase, putative
Trypanosoma cruzi TcCLB.506529.430   alanine aminotransferase, putative
Trypanosoma cruzi TcCLB.510889.140   glutamic--pyruvic transaminase, putative
Trypanosoma cruzi TcCLB.506529.420   alanine aminotransferase, putative
Toxoplasma gondii TGME49_264030   aminotransferase, putative
Trichomonas vaginalis TVAG_098820   tyrosine aminotransferase, putative
Trichomonas vaginalis TVAG_074600   tyrosine aminotransferase, putative
Trichomonas vaginalis TVAG_379550   tyrosine aminotransferase, putative
Trichomonas vaginalis TVAG_132440   alanine aminotransferase, putative
Trichomonas vaginalis TVAG_088220   aspartate aminotransferase, putative
Trichomonas vaginalis TVAG_136210   alanine aminotransferase, putative

Essentiality

Rv0337c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.3950 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.1.3950 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.3950 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.1.3950 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b2290 Escherichia coli non-essential goodall
CELE_C32F10.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C32F10.8 Caenorhabditis elegans larval arrest wormbase
CELE_C32F10.8 Caenorhabditis elegans slow growth wormbase
TGME49_264030 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0337c (Mycobacterium tuberculosis), Probable aspartate aminotransferase AspC (transaminase A) (ASPAT)
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