Detailed view for Rv0410c

Basic information

TDR Targets ID: 6799
Mycobacterium tuberculosis, SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STPK G)

Source Database / ID: Tuberculist / Rv0410c 

pI: 5.55 | Length (AA): 750 | MW (Da): 81577 | Number of Paralogs: -1

EC number(s): 2.7.1.- | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.11.1 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00069   Pkinase

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0005488   binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  

Process: (mouse over links to read term descriptions)

GO:0006468   protein amino acid phosphorylation  
Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: 2PZI  

Expression

Upregulation ranking: this gene ranks in the upper 60-80% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 34
Cumulative epitope score: 37.8
Normalized epitope score: 5.0
Percentile: 65.0 (this protein belongs to the top 35.0% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_26580
Number of Paralogs: -1

Ortholog group members from selected species:
Leishmania braziliensis LbrM22_V2.0850   |   OrthoMCL
Leishmania infantum LinJ22_V3.0770   |   OrthoMCL
Leishmania major LmjF22.0950   protein kinase, putative... |   OrthoMCL
Leishmania mexicana LmxM22.0950   |   OrthoMCL
Mycobacterium leprae strain TN ML0304   Probable serine-threonine protein kinase PknG (protein kinas... |   OrthoMCL
Mycobacterium tuberculosis Rv0410c (this record).   SERINE/THREONINE-PROTEIN KINASE PKNG (PROTEIN KINASE G) (STP... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053511817.210   protein kinase, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053510525.139   protein kinase, putative... |   OrthoMCL

Essentiality Rv0410c has essentiality data
Gene/Ortholog: (OG4_26580); Phenotype: essential; Source study: nmpdr

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from in vitro culture assay (ECO:0000182) [+/–] show term definition
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-31.
PubMed References: 15155913 15186418

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: decreased (PATO:0000468) [+/–] show term definition
Evidence: inferred from animal model system (ECO:0000179)
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-31.
PubMed References: 15186418

Affected entity: growth (GO:0040007) [+/–] show term definition

The increase in size or mass of an entire organism, a part of an organism or a cell. Synonym: growth pattern

Phenotypic quality: normal (PATO:0000461) [+/–] show term definition
Evidence: inferred from in vitro culture assay (ECO:0000182) [+/–] show term definition
Observed in: Mycobacterium tuberculosis (NEWT:1773)
Drugs/inhibitors: No drug identifiers listed for this gene.
Annotated by: crowther@u.washington.edu.
Comment: 2007-12-31.
PubMed References: 15155913

No validation aspects annotated for this target.

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    81 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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