Detailed view for Rv0446c

Basic information

TDR Targets ID: 980557
Mycobacterium tuberculosis, Possible conserved transmembrane protein
Source Database / ID:  Tuberculist 

pI: 11.026 | Length (AA): 256 | MW (Da): 28221 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06966  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016627   oxidoreductase activity, acting on the CH-CH group of donors  
GO:0016021   integral to membrane  
GO:0005737   cytoplasm  
GO:0006629   lipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130664)

Species Accession Gene Product
Arabidopsis thaliana AT1G18180   hypothetical protein
Dictyostelium discoideum DDB_G0279829   DUF1295 family protein
Drosophila melanogaster Dmel_CG6282   CG6282 gene product from transcript CG6282-RC
Mycobacterium tuberculosis Rv0446c   Possible conserved transmembrane protein
Mycobacterium ulcerans MUL_1401   transmembrane protein
Oryza sativa 4333864   Os03g0708400
Schmidtea mediterranea mk4.000467.08  
Trichomonas vaginalis TVAG_323660   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv0446c (Mycobacterium tuberculosis), Possible conserved transmembrane protein
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