Detailed view for Rv0486

Basic information

TDR Targets ID: 6537
Mycobacterium tuberculosis, Glycosyltransferase MshA
Source Database / ID:  Tuberculist 

pI: 7.6538 | Length (AA): 480 | MW (Da): 50541 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00534   Glycosyl transferases group 1
PF13439   Glycosyltransferase Family 4
PF13579  

Gene Ontology

Mouse over links to read term descriptions.
GO:0010125   mycothiol biosynthetic process  
GO:0008375   acetylglucosaminyltransferase activity  
GO:0009058   biosynthetic process  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 442 4rbn (A) 219 755 23.00 0 1 0.981933 0.34
44 457 3c48 (A) 0 418 50.00 0 1 1.4301 -0.47
137 439 4xso (B) 80 373 25.00 0 1 0.91335 -0.07
265 406 4x7r (A) 318 457 26.00 0.87 1 0.696833 -0.69

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_135052)

Species Accession Gene Product
Arabidopsis thaliana AT4G10120   probable sucrose-phosphate synthase 4
Arabidopsis thaliana AT5G11110   sucrose phosphate synthase 2F
Arabidopsis thaliana AT5G20280   sucrose phosphate synthase 1F
Arabidopsis thaliana AT1G04920   sucrose-phosphate synthase
Mycobacterium leprae ML2443c   GLYCOSYLTRANSFERASE MSHA
Mycobacterium tuberculosis Rv0486   Glycosyltransferase MshA
Mycobacterium ulcerans MUL_4556   mannosyltransferase
Oryza sativa 4350151   Os11g0236100
Oryza sativa 4328527   Os02g0184400
Oryza sativa 4345220   Os08g0301500

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
response to drug (GO:0042493) increased sensitivity toward (PATO:0001549) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis 322370   347521   561927   570798  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 15342574
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) inferred from loss-of-function mutant phenotype (ECO:0000016) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 17020551

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium leprae GLYCOSYLTRANSFERASE MSHA Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

95 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0486 (Mycobacterium tuberculosis), Glycosyltransferase MshA
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