Detailed view for Rv0491

Basic information

TDR Targets ID: 6996
Mycobacterium tuberculosis, TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPTIONAL REGULATORY PROTEIN) (PROBABLY LUXR-FAMILY)

Source Database / ID: Tuberculist / Rv0491 

pI: 4.58 | Length (AA): 227 | MW (Da): 24849 | Number of Paralogs: 1

EC number(s): No EC number(s) registered for this gene.

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF00072   Response_reg
PF00486   Trans_reg_C

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0003677   DNA binding  
GO:0000156   two-component response regulator activity  
Metabolic Pathways

Two-component system (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: 2OQR  

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 13
Cumulative epitope score: 14.6
Normalized epitope score: 6.4
Percentile: 97.6 (this protein belongs to the top 2.4% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_14119
Number of Paralogs: 1

Ortholog group members from selected species:
Escherichia coli K12 NP_414933.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Escherichia coli K12 NP_418348.1   DNA-binding response regulator in two-component regulatory s... |   OrthoMCL
Mycobacterium leprae strain TN ML2439c   TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPT... |   OrthoMCL
Mycobacterium tuberculosis Rv0491 (this record).   TWO COMPONENT SENSORY TRANSDUCTION PROTEIN REGX3 (TRANSCRIPT... |   OrthoMCL

Essentiality Rv0491 has essentiality data
Gene/Ortholog: mtu496 (OG4_14119); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco389 (OG4_14119); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco389 (OG4_14119); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco389 (OG4_14119); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco389 (OG4_14119); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: eco3770 (OG4_14119); Phenotype: non-essential; Source study: blattner
Gene/Ortholog: eco3770 (OG4_14119); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco3770 (OG4_14119); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco3770 (OG4_14119); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    No literature references are available for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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