Detailed view for Rv0500

Basic information

TDR Targets ID: 6929
Mycobacterium tuberculosis, PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C REDUCTASE)

Source Database / ID: Tuberculist / Rv0500 

pI: 4.42 | Length (AA): 295 | MW (Da): 30171 | Number of Paralogs: 0

EC number(s): 1.5.1.2 | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF03807   F420_oxidored

Gene Ontology

Function: (mouse over links to read term descriptions)

GO:0005488   binding  
GO:0004735   pyrroline-5-carboxylate reductase activity  
GO:0003824   catalytic activity  

Process: (mouse over links to read term descriptions)

GO:0008152   metabolic process  
GO:0006561   proline biosynthetic process  
Metabolic Pathways

Arginine and proline metabolism (KEGG)
Global map (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the lower 0-20% group of genes.
Shows this level of upregulation in: Dormant phase, Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 11
Cumulative epitope score: 12.5
Normalized epitope score: 4.3
Percentile: 28.2 (this protein belongs to the top 71.8% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_10273
Number of Paralogs: 0

Ortholog group members from selected species:
Arabidopsis thaliana NP_001078584   P5CR (PYRROLINE-5- CARBOXYLATE (P5C) REDUCTASE); pyrroline-... |   OrthoMCL
Arabidopsis thaliana NP_196984   P5CR (PYRROLINE-5- CARBOXYLATE (P5C) REDUCTASE); pyrroline-... |   OrthoMCL
Brugia malayi Bm1_38015   pyrroline-5-carboxylate reductase family protein... |   OrthoMCL
Caenorhabditis elegans M153.1   CE03511 WBGene00010924 pyrroline-5-carboxylate reductase sta... |   OrthoMCL
Cryptosporidium hominis Chro.60426   pyrroline-5-carboxylate reductase ... |   OrthoMCL
Cryptosporidium muris CMU_016970   pyrroline-5-carboxylate reductase family protein ... |   OrthoMCL
Cryptosporidium neoformas XP_571245   pyrroline-5-carboxylate reductase ... |   OrthoMCL
Cryptosporidium parvum cgd6_3720   pyrroline-5-carboxylate reductase ... |   OrthoMCL
Drosophila melanogaster FBpp0082895   |   OrthoMCL
Drosophila melanogaster FBpp0083127   |   OrthoMCL
Escherichia coli K12 NP_414920.1   pyrroline-5-carboxylate reductase [Escherichia coli K12]... |   OrthoMCL
Homo sapiens ENSP00000220966   |   OrthoMCL
Homo sapiens ENSP00000414068   |   OrthoMCL
Leishmania braziliensis LbrM13_V2.1540   |   OrthoMCL
Leishmania infantum LinJ13_V3.1420   |   OrthoMCL
Leishmania major LmjF13.1680   pyrroline-5-carboxylate reductase... |   OrthoMCL
Leishmania mexicana LmxM13.1680   |   OrthoMCL
Mycobacterium leprae strain TN ML2430c   PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C ... |   OrthoMCL
Mus musculus ENSMUSP00000026133   |   OrthoMCL
Mus musculus ENSMUSP00000027802   |   OrthoMCL
Mus musculus ENSMUSP00000049605   |   OrthoMCL
Mycobacterium tuberculosis Rv0500 (this record).   PROBABLE PYRROLINE-5-CARBOXYLATE REDUCTASE PROC (P5CR) (P5C ... |   OrthoMCL
Neospora caninum NCLIV_050390   |   OrthoMCL
Oryza sativa NP_001045393   Os01g0948400 ... |   OrthoMCL
Plasmodium berghei PB001079.00.0   hypothetical protein ... |   OrthoMCL
Plasmodium berghei PB300754.00.0   pyrroline carboxylate reductase, putative ... |   OrthoMCL
Plasmodium chabaudi PCAS_113370   pyrroline carboxylate reductase, putative ... |   OrthoMCL
P. falciparum 3D7 MAL13P1.284   pyrroline carboxylate reductase... |   OrthoMCL
Plasmodium knowlesi PKH_111310   Pyrroline carboxylate reductase, putative ... |   OrthoMCL
Plasmodium vivax PVX_114870   pyrroline carboxylate reductase, putative... |   OrthoMCL
Plasmodium yoelii PY02938   pyrroline-5-carboxylate reductase ... |   OrthoMCL
Saccharomyces cerevisiae YER023W   PRO3 SGDID:S000000825, Chr V from 201075-201935, Verified OR... |   OrthoMCL
Schistosoma mansoni Smp_049390   pyrroline-5-carboxylate reductase... |   OrthoMCL
Trypanosoma brucei gambiense Tbg972.7.2720   |   OrthoMCL
Trypanosoma brucei Tb927.7.2440   pyrroline-5-carboxylate reductase, putative... |   OrthoMCL
Trypanosoma congolense TcIL3000.7.1750   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053509207.90   pyrroline-5-carboxylate reductase, putative... |   OrthoMCL
Trypanosoma cruzi Tc00.1047053506857.20   pyrroline-5-carboxylate reductase, putative... |   OrthoMCL
Toxoplasma gondii TGME49_036070   pyrroline-5-carboxylate reductase, putative... |   OrthoMCL
Trypanosoma vivax TvY486_0702280   |   OrthoMCL

Essentiality Rv0500 has essentiality data
Gene/Ortholog: mtu506 (OG4_10273); Phenotype: essential; Source study: nmpdr
Gene/Ortholog: sce1737 (OG4_10273); Phenotype: inviable; Source study: yeastgenome
Gene/Ortholog: eco377 (OG4_10273); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco377 (OG4_10273); Phenotype: essential; Source study: gerdes
Gene/Ortholog: eco377 (OG4_10273); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco377 (OG4_10273); Phenotype: non-essential; Source study: shigen
Gene/Ortholog: Tb927.7.2440 (OG4_10273); Phenotype: no significant loss or gain of fitness in bloodstream forms (3 days); Source study: alsford
Gene/Ortholog: Tb927.7.2440 (OG4_10273); Phenotype: significant loss of fitness in bloodstream forms (6 days); Source study: alsford
Gene/Ortholog: Tb927.7.2440 (OG4_10273); Phenotype: significant loss of fitness in procyclic forms; Source study: alsford
Gene/Ortholog: Tb927.7.2440 (OG4_10273); Phenotype: significant loss of fitness in differentiation of procyclic to bloodstream forms; Source study: alsford

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability
  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    1 literature reference was collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

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