pI: 4.6927 |
Length (AA): 701 |
MW (Da): 77170 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 695 | 1dar (A) | 1 | 688 | 60.00 | 0 | 1 | 1.53094 | 0.07 |
8 | 701 | 2xex (A) | 5 | 693 | 61.00 | 0 | 1 | 1.65751 | -0.41 |
10 | 406 | 5vh6 (A) | 7 | 400 | 63.00 | 0 | 1 | 1.29233 | -0.74 |
611 | 701 | 5h7j (A) | 628 | 721 | 34.00 | 0 | 0.93 | 0.593315 | -0.97 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126692)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G45030 | elongation factor EF-G |
Arabidopsis thaliana | AT1G45332 | elongation factor G |
Arabidopsis thaliana | AT1G62750 | elongation factor G |
Babesia bovis | BBOV_III000360 | translation elongation factor G, putative |
Babesia bovis | BBOV_IV004710 | translation elongation factor G (EF-G), putative |
Brugia malayi | Bm1_50625 | Elongation factor G C-terminus family protein |
Candida albicans | CaO19.6208 | Mitochondrial elongation factor G-like protein |
Candida albicans | CaO19.13589 | Mitochondrial elongation factor G-like protein |
Candida albicans | CaO19.12398 | Mitochondrial elongation factor G-like protein |
Candida albicans | CaO19.4932 | Mitochondrial elongation factor G-like protein |
Caenorhabditis elegans | CELE_Y119D3B.14 | Protein Y119D3B.14 |
Caenorhabditis elegans | CELE_F29C12.4 | Protein F29C12.4 |
Chlamydia trachomatis | CT_437 | elongation factor G |
Dictyostelium discoideum | DDB_G0267766 | mitochondrial translation elongation factor G |
Dictyostelium discoideum | DDB_G0270482 | mitochondrial translation elongation factor G |
Drosophila melanogaster | Dmel_CG4567 | iconoclast |
Drosophila melanogaster | Dmel_CG31159 | Elongation Factor G2 |
Escherichia coli | b3340 | protein chain elongation factor EF-G, GTP-binding |
Echinococcus granulosus | EgrG_000424300 | translation elongation factor G |
Echinococcus granulosus | EgrG_000697600 | elongation factor G mitochondrial |
Echinococcus granulosus | EgrG_000424400 | translation elongation factor G |
Echinococcus multilocularis | EmuJ_000697600 | elongation factor G, mitochondrial |
Echinococcus multilocularis | EmuJ_000424400 | translation elongation factor G |
Homo sapiens | ENSG00000168827 | G elongation factor, mitochondrial 1 |
Homo sapiens | ENSG00000164347 | G elongation factor, mitochondrial 2 |
Leishmania braziliensis | LbrM.28.2160 | elongation factor G2-like protein |
Leishmania braziliensis | LbrM.35.0680 | Mitochondrial elongation factor G, putative |
Leishmania donovani | LdBPK_360620.1 | Elongation factor G1, mitochondrial, putative |
Leishmania donovani | LdBPK_282090.1 | Elongation factor G 2, mitochondrial, putative |
Leishmania infantum | LinJ.36.0620 | Mitochondrial elongation factor G, putative |
Leishmania infantum | LinJ.28.2090 | elongation factor G2-like protein |
Leishmania major | LmjF.28.1960 | elongation factor G2-like protein |
Leishmania major | LmjF.36.0570 | Mitochondrial elongation factor G, putative |
Leishmania mexicana | LmxM.28.1960 | elongation factor G2-like protein |
Leishmania mexicana | LmxM.36.0570 | Mitochondrial elongation factor G, putative |
Loa Loa (eye worm) | LOAG_03866 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14564 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03914 | hypothetical protein |
Mycobacterium leprae | ML1878c | PROBABLE ELONGATION FACTOR G FUSA1 (EF-G) |
Mus musculus | 28030 | G elongation factor, mitochondrial 1 |
Mus musculus | ENSMUSG00000021666 | G elongation factor, mitochondrial 2 |
Mycobacterium tuberculosis | Rv0684 | Probable elongation factor G FusA1 (EF-G) |
Mycobacterium ulcerans | MUL_0765 | elongation factor G |
Neospora caninum | NCLIV_048540 | elongation factor G, putative |
Neospora caninum | NCLIV_026830 | Translation elongation factor G, related |
Oryza sativa | 4336525 | Os04g0538100 |
Oryza sativa | 4333268 | Os03g0565500 |
Onchocerca volvulus | OVOC13440 |
|
Plasmodium berghei | PBANKA_0101200 | elongation factor G, putative |
Plasmodium berghei | PBANKA_1447700 | elongation factor G, putative |
Plasmodium falciparum | PF3D7_0602400 | elongation factor G |
Plasmodium falciparum | PF3D7_1233000 | elongation factor G |
Plasmodium knowlesi | PKNH_1452500 | elongation factor G, putative |
Plasmodium knowlesi | PKNH_1148300 | elongation factor G, putative |
Plasmodium vivax | PVX_100600 | elongation factor G, putative |
Plasmodium vivax | PVX_113285 | elongation factor G, putative |
Plasmodium yoelii | PY04706 | translation elongation factor G |
Plasmodium yoelii | PY01864 | elongation factor g-related |
Saccharomyces cerevisiae | YLR069C | Mef1p |
Saccharomyces cerevisiae | YJL102W | Mef2p |
Schistosoma japonicum | Sjp_0122460 | expressed protein |
Schistosoma japonicum | Sjp_0306820 | Elongation factor G 2, mitochondrial precursor, putative |
Schistosoma japonicum | Sjp_0037430 | Elongation factor G 1, mitochondrial precursor, putative |
Schistosoma japonicum | Sjp_0057090 | Elongation factor G, putative |
Schistosoma japonicum | Sjp_0080540 | ko:K02355 elongation factor EF-G, putative |
Schistosoma mansoni | Smp_075690 | translation elongation factor G |
Schistosoma mansoni | Smp_165840.2 | translation elongation factor G |
Schistosoma mansoni | Smp_165840.1 | translation elongation factor G |
Schmidtea mediterranea | mk4.034240.00 | |
Schmidtea mediterranea | mk4.012015.01 | Ribosome-releasing factor 2, mitochondrial |
Schmidtea mediterranea | mk4.000296.04 | Ribosome-releasing factor 2, mitochondrial |
Schmidtea mediterranea | mk4.001580.04 | |
Schmidtea mediterranea | mk4.001580.03 | |
Schmidtea mediterranea | mk4.016148.01 | |
Trypanosoma brucei gambiense | Tbg972.11.10040 | elongation factor G2-like protein, putative |
Trypanosoma brucei gambiense | Tbg972.10.6060 | Mitochondrial elongation factor G, putative |
Trypanosoma brucei | Tb927.10.5010 | Elongation factor G1, mitochondrial, putative |
Trypanosoma brucei | Tb927.11.8980 | Elongation factor G 2, mitochondrial, putative |
Trypanosoma congolense | TcIL3000.11.9290 | Elongation factor G 2, mitochondrial, putative |
Trypanosoma congolense | TcIL3000_10_4190 | Elongation factor G1, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.509205.110 | elongation factor G2-like protein, putative |
Trypanosoma cruzi | TcCLB.509199.10 | Elongation factor G 2, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.508601.130 | Elongation factor G 2, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.506583.60 | Elongation factor G1, mitochondrial, putative |
Toxoplasma gondii | TGME49_223970 | translation elongation and release factors (gtpases), putative |
Toxoplasma gondii | TGME49_260170 | elongation factor EF-G, putative |
Treponema pallidum | TP0450 | elongation factor G |
Treponema pallidum | TP0767 | elongation factor G |
Theileria parva | TP03_0816 | elongation factor G, putative |
Theileria parva | TP01_0278 | translation elongation factor G 2, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0344 | elongation factor G |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.0710 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.0710 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.0710 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.01.0710 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.5010 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.5010 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.5010 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.5010 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3340 | Escherichia coli | essential | goodall |
CELE_F29C12.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F29C12.4 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F29C12.4 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_0101200 | Plasmodium berghei | Essential | plasmo |
PBANKA_1447700 | Plasmodium berghei | Essential | plasmo |
TGME49_260170 | Toxoplasma gondii | Probably essential | sidik |
TGME49_223970 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.