Detailed view for Rv0706

Basic information

TDR Targets ID: 7052
Mycobacterium tuberculosis, 50S ribosomal protein L22 RplV
Source Database / ID:  Tuberculist 

pI: 12.2662 | Length (AA): 197 | MW (Da): 20380 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00237   Ribosomal protein L22p/L17e

Gene Ontology

Mouse over links to read term descriptions.
GO:0015934   large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 123 5dm6 (P) 14 134 47.00 0 1 1.19701 -0.31
12 123 1i4j (A) 2 113 50.00 0.0000000000067 1 1.21253 -0.71
12 122 4wfa (P) 2 112 49.00 0 1 1.20745 -0.61
119 194 2l7a (A) 803 879 17.00 0 0.04 0.608587 -0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_128312)

Species Accession Gene Product
Arabidopsis thaliana ArthCp062   ribosomal protein L22
Arabidopsis thaliana AT4G28360   ribosomal protein L22p/L17e family protein
Arabidopsis thaliana AT1G52370   ribosomal protein L22p/L17e family protein
Brugia malayi Bm1_54235   RE06857p
Caenorhabditis elegans CELE_Y39A1A.6   Protein MRPL-22
Chlamydia trachomatis CT_523   50S ribosomal protein L22
Dictyostelium discoideum DDB_G0279519   ribosomal protein L22, mitochondrial
Drosophila melanogaster Dmel_CG4742   mitochondrial ribosomal protein L22
Escherichia coli b3315   50S ribosomal subunit protein L22
Echinococcus granulosus EgrG_001031900   DDE superfamily endonuclease CENP B
Echinococcus granulosus EgrG_000978400   39S ribosomal protein L22 mitochondrial
Echinococcus multilocularis EmuJ_000978400   39S ribosomal protein L22, mitochondrial
Echinococcus multilocularis EmuJ_001031900   DDE superfamily endonuclease, CENP B
Homo sapiens ENSG00000082515   mitochondrial ribosomal protein L22
Loa Loa (eye worm) LOAG_05144   hypothetical protein
Mycobacterium leprae ML1858c   PROBABLE 50S RIBOSOMAL PROTEIN L22 RPLV
Mus musculus ENSMUSG00000020514   mitochondrial ribosomal protein L22
Mycobacterium tuberculosis Rv0706   50S ribosomal protein L22 RplV
Mycobacterium ulcerans MUL_0795   50S ribosomal protein L22
Neospora caninum NCLIV_056820   50S ribosomal protein L22, putative
Oryza sativa 3131426   ribosomal protein L22
Oryza sativa 4326653   Os01g0616500
Oryza sativa 9272040   Os08g0252001
Schistosoma japonicum Sjp_0214750   ko:K02890 large subunit ribosomal protein L22, putative
Schistosoma japonicum Sjp_0047120   IPR007889,Helix-turn-helix, Psq;IPR009057,Homeodomain-like,domain-containing
Schistosoma mansoni Smp_162130   hypothetical protein
Schmidtea mediterranea mk4.002037.02   39S ribosomal protein L22, mitochondrial
Schmidtea mediterranea mk4.014894.00   39S ribosomal protein L22, mitochondrial
Toxoplasma gondii TGME49_313550   ribosomal protein RPL22
Treponema pallidum TP0194   50S ribosomal protein L22
Wolbachia endosymbiont of Brugia malayi Wbm0336   50S ribosomal protein L22

Essentiality

Rv0706 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu718 this record Mycobacterium tuberculosis essential nmpdr
b3315 Escherichia coli essential goodall
CELE_Y39A1A.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y39A1A.6 Caenorhabditis elegans larval arrest wormbase
CELE_Y39A1A.6 Caenorhabditis elegans sterile wormbase
TGME49_313550 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0706 (Mycobacterium tuberculosis), 50S ribosomal protein L22 RplV
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