pI: 4.2376 |
Length (AA): 801 |
MW (Da): 65407 |
Paralog Number:
49
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
152 | 227 | 2pne (A) | 6 | 81 | 34.00 | 0.0084 | 0.45 | 0.347381 | 0.99 |
313 | 352 | 3bog (C) | 3 | 79 | 65.00 | 0.000084 | 0.24 | 0.725138 | -0.86 |
470 | 565 | 2pne (A) | 3 | 80 | 58.00 | 0.0000000025 | 0.97 | 0.40905 | 1.53 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Dormant phase. | murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_129879)
Species | Accession | Gene Product |
---|---|---|
Mycobacterium tuberculosis | Rv0109 | PE-PGRS family protein PE_PGRS1 |
Mycobacterium tuberculosis | Rv0747 | PE-PGRS family protein PE_PGRS10 |
Mycobacterium tuberculosis | Rv0754 | PE-PGRS family protein PE_PGRS11 |
Mycobacterium tuberculosis | Rv0833 | PE-PGRS family protein PE_PGRS13 |
Mycobacterium tuberculosis | Rv0834c | PE-PGRS family protein PE_PGRS14 |
Mycobacterium tuberculosis | Rv0872c | PE-PGRS family protein PE_PGRS15 |
Mycobacterium tuberculosis | Rv0978c | PE-PGRS family protein PE_PGRS17 |
Mycobacterium tuberculosis | Rv0980c | PE-PGRS family protein PE_PGRS18 |
Mycobacterium tuberculosis | Rv1067c | PE-PGRS family protein PE_PGRS19 |
Mycobacterium tuberculosis | Rv0124 | PE-PGRS family protein PE_PGRS2 |
Mycobacterium tuberculosis | Rv1068c | PE-PGRS family protein PE_PGRS20 |
Mycobacterium tuberculosis | Rv1087 | PE-PGRS family protein PE_PGRS21 |
Mycobacterium tuberculosis | Rv1091 | PE-PGRS family protein PE_PGRS22 |
Mycobacterium tuberculosis | Rv1243c | PE-PGRS family protein PE_PGRS23 |
Mycobacterium tuberculosis | Rv1325c | PE-PGRS family protein PE_PGRS24 |
Mycobacterium tuberculosis | Rv1396c | PE-PGRS family protein PE_PGRS25 |
Mycobacterium tuberculosis | Rv1441c | PE-PGRS family protein PE_PGRS26 |
Mycobacterium tuberculosis | Rv1450c | PE-PGRS family protein PE_PGRS27 |
Mycobacterium tuberculosis | Rv1452c | PE-PGRS family protein PE_PGRS28 |
Mycobacterium tuberculosis | Rv1468c | PE-PGRS family protein PE_PGRS29 |
Mycobacterium tuberculosis | Rv0278c | PE-PGRS family protein PE_PGRS3 |
Mycobacterium tuberculosis | Rv1768 | PE-PGRS family protein PE_PGRS31 |
Mycobacterium tuberculosis | Rv1818c | PE-PGRS family protein PE_PGRS33 |
Mycobacterium tuberculosis | Rv1840c | PE-PGRS family protein PE_PGRS34 |
Mycobacterium tuberculosis | Rv2162c | PE-PGRS family protein PE_PGRS38 |
Mycobacterium tuberculosis | Rv2340c | PE-PGRS family protein PE_PGRS39 |
Mycobacterium tuberculosis | Rv0279c | PE-PGRS family protein PE_PGRS4 |
Mycobacterium tuberculosis | Rv2396 | PE-PGRS family protein PE_PGRS41 |
Mycobacterium tuberculosis | Rv2487c | PE-PGRS family protein PE_PGRS42 |
Mycobacterium tuberculosis | Rv2490c | PE-PGRS family protein PE_PGRS43 |
Mycobacterium tuberculosis | Rv2591 | PE-PGRS family protein PE_PGRS44 |
Mycobacterium tuberculosis | Rv2615c | PE-PGRS family protein PE_PGRS45 |
Mycobacterium tuberculosis | Rv2634c | PE-PGRS family protein PE_PGRS46 |
Mycobacterium tuberculosis | Rv2741 | PE-PGRS family protein PE_PGRS47 |
Mycobacterium tuberculosis | Rv2853 | PE-PGRS family protein PE_PGRS48 |
Mycobacterium tuberculosis | Rv1759c | PE-PGRS family protein Wag22 |
Mycobacterium tuberculosis | Rv3345c | PE-PGRS family protein PE_PGRS50 |
Mycobacterium tuberculosis | Rv3367 | PE-PGRS family protein PE_PGRS51 |
Mycobacterium tuberculosis | Rv3388 | PE-PGRS family protein PE_PGRS52 |
Mycobacterium tuberculosis | Rv3507 | PE-PGRS family protein PE_PGRS53 |
Mycobacterium tuberculosis | Rv3508 | PE-PGRS family protein PE_PGRS54 |
Mycobacterium tuberculosis | Rv3511 | PE-PGRS family protein PE_PGRS55 |
Mycobacterium tuberculosis | Rv3514 | PE-PGRS family protein PE_PGRS57 |
Mycobacterium tuberculosis | Rv3590c | PE-PGRS family protein PE_PGRS58 |
Mycobacterium tuberculosis | Rv3595c | PE-PGRS family protein PE_PGRS59 |
Mycobacterium tuberculosis | Rv0532 | PE-PGRS family protein PE_PGRS6 |
Mycobacterium tuberculosis | Rv0578c | PE-PGRS family protein PE_PGRS7 |
Mycobacterium tuberculosis | Rv0746 | PE-PGRS family protein PE_PGRS9 |
Mycobacterium tuberculosis | Rv3390 | Probable conserved lipoprotein LpqD |
Mycobacterium tuberculosis | Rv1983 | PE-PGRS family protein PE_PGRS35 |
Mycobacterium ulcerans | MUL_2702 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_0919 | lipoprotein LpqD |
Mycobacterium ulcerans | MUL_1870 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3982 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_1639 | PE-PGRS family protein |
Mycobacterium ulcerans | MUL_3440 | hypothetical protein |
Mycobacterium ulcerans | MUL_2395 | PE family protein |
Mycobacterium ulcerans | MUL_3975 | PE-PGRS family protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3450 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu760 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu768 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu888 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1084 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1264 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1348 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1419 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1464 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1491 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1848 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1870 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2196 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2381 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2437 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2635 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2661 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2680 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2900 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3427 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3568 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3652 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3657 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu586 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1789 | Mycobacterium tuberculosis | non-essential | nmpdr |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5