pI: 10.4533 |
Length (AA): 540 |
MW (Da): 56587 |
Paralog Number:
5
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 13
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
69 | 384 | 3b9y (A) | 37 | 366 | 17.00 | 0 | 0.23 | 0.551085 | 0.81 |
77 | 452 | 5xas (A) | 81 | 439 | 16.00 | 0 | 0.88 | 0.692196 | 0.66 |
110 | 410 | 3zux (A) | 19 | 301 | 16.00 | 0 | 0.2 | 0.646307 | -0.06 |
206 | 352 | 4rfs (S) | 41 | 190 | 35.00 | 0.19 | 0.57 | 0.415322 | 0.94 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126664)
Species | Accession | Gene Product |
---|---|---|
Candida albicans | CaO19.7336 | one of two genes (CaP19.7554 and CaP19.7336) similar to pichia anomala putative transporter (CAC69145) |
Candida albicans | CaO19.8888 | similar to S. pombe fnx1 (SPBC12C2.13c) MSF-MDR transporter implicated in G0 transition |
Candida albicans | CaO19.12243 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Candida albicans | CaO19.4779 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Candida albicans | CaO19.3444 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Candida albicans | CaO19.10948 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Candida albicans | CaO19.1942 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Candida albicans | CaO19.1308 | similar to S. pombe fnx1 (SPBC12C2.13c) MSF-MDR transporter implicated in G0 transition |
Candida albicans | CaO19.9497 | one of three related potential transporter genes (CaP19.1942, CaP19.3444 and CaP19.4779) similar to S. cerevisiae YKR105C, YCL06 |
Dictyostelium discoideum | DDB_G0283345 | drug resistance transporter, EmrB/QacA subfamily protein |
Escherichia coli | b2686 | multidrug efflux system protein |
Escherichia coli | b1828 | putative transporter |
Escherichia coli | b2367 | putative multidrug efflux system |
Giardia lamblia | GL50803_8444 | MDR-type permease |
Giardia lamblia | GL50803_16880 | Multidrug resistance protein B |
Mycobacterium leprae | ML1562c | POSSIBLE INTEGRAL MEMBRANE EFFLUX PROTEIN EFPA |
Mycobacterium tuberculosis | Rv1877 | Probable conserved integral membrane protein |
Mycobacterium tuberculosis | Rv0783c | Possible multidrug resistance integral membrane efflux protein EmrB |
Mycobacterium tuberculosis | Rv2333c | Integral membrane drug efflux protein Stp |
Mycobacterium tuberculosis | Rv3239c | Probable conserved transmembrane transport protein |
Mycobacterium tuberculosis | Rv3728 | Probable conserved two-domain membrane protein |
Mycobacterium tuberculosis | Rv2459 | Probable conserved integral membrane transport protein |
Mycobacterium ulcerans | MUL_0240 | hypothetical protein |
Mycobacterium ulcerans | MUL_3826 | hypothetical protein |
Mycobacterium ulcerans | MUL_1468 | integral membrane transport protein |
Mycobacterium ulcerans | MUL_0542 | multidrug resistance integral membrane efflux protein |
Mycobacterium ulcerans | MUL_0501 | integral membrane drug efflux protein |
Mycobacterium ulcerans | MUL_3729 | integral membrane transport protein |
Mycobacterium ulcerans | MUL_3590 | transmembrane transport protein |
Saccharomyces cerevisiae | YGR224W | Azr1p |
Saccharomyces cerevisiae | YMR088C | Vba1p |
Saccharomyces cerevisiae | YCL069W | Vba3p |
Saccharomyces cerevisiae | YKR105C | Vba5p |
Saccharomyces cerevisiae | YPR198W | Sge1p |
Saccharomyces cerevisiae | YDR119W | Vba4p |
Schmidtea mediterranea | mk4.065124.00 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu798 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu1907 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2374 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu2502 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu3298 | Mycobacterium tuberculosis | non-essential | nmpdr |
b1828 | Escherichia coli | non-essential | goodall |
b2367 | Escherichia coli | non-essential | goodall |
b2686 | Escherichia coli | non-essential | goodall |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1