pI: 5.6408 |
Length (AA): 303 |
MW (Da): 31229 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 300 | 2nu8 (A) | 1 | 287 | 52.00 | 0 | 1 | 1.6635 | -1.35 |
5 | 300 | 2fp4 (A) | 9 | 300 | 49.00 | 0 | 1 | 1.6165 | -1.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase, Dormant phase. | hasan murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127106)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G08300 | Succinyl-CoA ligase [GDP-forming] subunit alpha-1 |
Arabidopsis thaliana | AT5G23250 | Succinyl-CoA ligase [GDP-forming] subunit alpha-2 |
Babesia bovis | BBOV_III007780 | succinyl-CoA synthetase, alpha subunit family protein |
Brugia malayi | Bm1_00350 | succinyl-CoA ligase [GDP-forming] alpha-chain, mitochindrial |
Candida albicans | CaO19.3358 | succinate-CoA ligase |
Candida albicans | CaO19.10866 | succinate-CoA ligase |
Caenorhabditis elegans | CELE_F23H11.3 | Protein SUCL-2 |
Caenorhabditis elegans | CELE_C05G5.4 | Protein SUCL-1 |
Chlamydia trachomatis | CT_822 | succinyl-CoA ligase subunit alpha |
Dictyostelium discoideum | DDB_G0289325 | GTP-specific succinyl-CoA synthetase alpha subunit |
Drosophila melanogaster | Dmel_CG6255 | CG6255 gene product from transcript CG6255-RA |
Drosophila melanogaster | Dmel_CG1065 | Succinyl coenzyme A synthetase alpha subunit |
Escherichia coli | b0729 | succinyl-CoA synthetase, NAD(P)-binding, alpha subunit |
Echinococcus granulosus | EgrG_001199000 | succinyl coenzyme A synthetase alpha subunit |
Echinococcus multilocularis | EmuJ_001199000 | succinyl coenzyme A synthetase alpha subunit |
Homo sapiens | ENSG00000163541 | succinate-CoA ligase, alpha subunit |
Leishmania braziliensis | LbrM.25.1710 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania braziliensis | LbrM.25.1700 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania donovani | LdBPK_252220.1 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania infantum | LinJ.25.2230 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania major | LmjF.25.2140 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania major | LmjF.25.2130 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania mexicana | LmxM.25.2140 | succinyl-CoA synthetase alpha subunit, putative |
Leishmania mexicana | LmxM.25.2130 | succinyl-CoA synthetase alpha subunit, putative |
Loa Loa (eye worm) | LOAG_11959 | hypothetical protein |
Loa Loa (eye worm) | LOAG_07230 | succinate-CoA ligase |
Mycobacterium leprae | ML0156 | Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) |
Mus musculus | ENSMUSG00000052738 | succinate-CoA ligase, GDP-forming, alpha subunit |
Mycobacterium tuberculosis | Rv0952 | Probable succinyl-CoA synthetase (alpha chain) SucD (SCS-alpha) |
Mycobacterium ulcerans | MUL_4719 | succinyl-CoA synthetase subunit alpha |
Neospora caninum | NCLIV_042590 | 2-oxoglutarate dehydrogenase E1 component, related |
Oryza sativa | 4343710 | Os07g0577700 |
Onchocerca volvulus | OVOC5451 |
|
Plasmodium berghei | PBANKA_0938500 | succinyl-CoA synthetase alpha subunit, putative |
Plasmodium falciparum | PF3D7_1108500 | succinyl-CoA synthetase alpha subunit, putative |
Plasmodium knowlesi | PKNH_0906100 | succinyl-CoA synthetase alpha subunit, putative |
Plasmodium vivax | PVX_091100 | succinyl-CoA synthetase alpha subunit, putative |
Plasmodium yoelii | PY05049 | Succinyl-CoA synthetase alpha subunit |
Saccharomyces cerevisiae | YOR142W | succinate--CoA ligase (GDP-forming) subunit alpha |
Schistosoma japonicum | Sjp_0303530 | ko:K01899 succinate--CoA ligase (GDP-forming) alpha chain [EC6.2.1.4A], putative |
Schistosoma mansoni | Smp_052060 | succinyl-CoA synthetase-related |
Schmidtea mediterranea | mk4.000163.09 | Succinyl-CoA ligase |
Schmidtea mediterranea | mk4.058520.01 | |
Trypanosoma brucei gambiense | Tbg972.3.2200 | succinyl-CoA synthetase alpha subunit, putative |
Trypanosoma brucei | Tb927.3.2230 | succinyl-CoA synthetase alpha subunit, putative |
Trypanosoma congolense | TcIL3000_3_1350 | succinyl-CoA synthetase alpha subunit, putative |
Trypanosoma cruzi | TcCLB.508479.340 | succinyl-CoA synthetase alpha subunit, putative |
Toxoplasma gondii | TGME49_290600 | succinyl-CoA-synthetase alpha SCSA |
Theileria parva | TP04_0660 | succinyl-CoA synthetase, alpha subunit, putative |
Trichomonas vaginalis | TVAG_318670 | succinate thiokinase a subunit |
Trichomonas vaginalis | TVAG_047890 | succinate thiokinase a subunit |
Trichomonas vaginalis | TVAG_165340 | succinate thiokinase a subunit |
Wolbachia endosymbiont of Brugia malayi | Wbm0519 | succinyl-CoA synthetase, alpha subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu967 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.3.2230 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2230 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2230 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.2230 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0729 | Escherichia coli | non-essential | goodall |
CELE_C05G5.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F23H11.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0938500 | Plasmodium berghei | Slow | plasmo |
TGME49_290600 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5