pI: 9.5028 |
Length (AA): 770 |
MW (Da): 80103 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 6
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 72 | 3dxs (X) | 4 | 74 | 20.00 | 0.0048 | 0.46 | 0.410407 | -1.23 |
1 | 58 | 1afi (A) | 5 | 61 | 18.00 | 0.0000081 | 0.14 | 0.227225 | -0.1 |
4 | 42 | 1mwy (A) | 9 | 46 | 32.00 | 0.004 | 0.24 | 0.275549 | 0.57 |
133 | 762 | 4bbj (A) | 77 | 733 | 43.00 | 0 | 1 | 1.28208 | -0.03 |
251 | 363 | 2hc8 (A) | 214 | 326 | 61.00 | 0 | 1 | 0.950053 | -1.04 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Dormant phase, Dormant phase. | hasan murphy |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_126855)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G63440 | putative copper-transporting ATPase HMA5 |
Arabidopsis thaliana | AT5G44790 | copper-transporting ATPase RAN1 |
Brugia malayi | Bm1_00795 | E1-E2 ATPase family protein |
Candida albicans | CaO19.4328 | copper-transporting ATPase |
Candida albicans | CaO19.11803 | copper-transporting ATPase |
Caenorhabditis elegans | CELE_Y76A2A.2 | Protein CUA-1, isoform B |
Cryptosporidium hominis | Chro.30424 | P-type ATPase 2 |
Cryptosporidium parvum | cgd3_3740 | P-type ATPase 2 |
Dictyostelium discoideum | DDB_G0273235 | P-type ATPase |
Dictyostelium discoideum | DDB_G0284141 | P-type ATPase |
Dictyostelium discoideum | DDB_G0273675 | P-type ATPase |
Drosophila melanogaster | Dmel_CG1886 | CG1886 gene product from transcript CG1886-RC |
Escherichia coli | b0484 | copper transporter |
Echinococcus granulosus | EgrG_001195000 | copper transporting ATPase 1 |
Echinococcus multilocularis | EmuJ_001195000 | copper transporting ATPase 1 |
Homo sapiens | ENSG00000123191 | ATPase, Cu++ transporting, beta polypeptide |
Homo sapiens | ENSG00000165240 | ATPase, Cu++ transporting, alpha polypeptide |
Leishmania braziliensis | LbrM.33.2370 | copper-transporting ATPase-like protein, putative |
Leishmania donovani | LdBPK_332210.1 | copper-transporting ATPase-like protein, putative |
Leishmania infantum | LinJ.33.2210 | copper-transporting ATPase-like protein, putative |
Leishmania major | LmjF.33.2090 | copper-transporting ATPase-like protein, putative |
Leishmania mexicana | LmxM.32.2090 | copper-transporting ATPase-like protein, putative |
Loa Loa (eye worm) | LOAG_09008 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01704 | hypothetical protein |
Mycobacterium leprae | ML2000c | PROBABLE CATION-TRANSPORTER P-TYPE ATPASE B CTPB |
Mycobacterium leprae | ML1987 | PROBABLE CATION TRANSPORTER P-TYPE ATPASE A CTPA |
Mus musculus | 11977 | ATPase, Cu++ transporting, alpha polypeptide |
Mus musculus | ENSMUSG00000006567 | ATPase, Cu++ transporting, beta polypeptide |
Mycobacterium tuberculosis | Rv0103c | Probable cation-transporter P-type ATPase B CtpB |
Mycobacterium tuberculosis | Rv0092 | Cation transporter P-type ATPase a CtpA |
Mycobacterium tuberculosis | Rv0969 | Probable metal cation transporter P-type ATPase CtpV |
Mycobacterium ulcerans | MUL_4845 | cation-transporter p-type ATPase B CtpB |
Mycobacterium ulcerans | MUL_4850 | cation transporter p-type ATPase a CtpA |
Mycobacterium ulcerans | MUL_0423 | metal cation transporter p-type ATPase, CtpV |
Neospora caninum | NCLIV_023240 | Heavy metal translocating P-type ATPase, related |
Oryza sativa | 4328616 | Os02g0196600 |
Oryza sativa | 4341778 | Os06g0665800 |
Oryza sativa | 4336625 | Os04g0556000 |
Oryza sativa | 4328448 | Os02g0172600 |
Plasmodium berghei | PBANKA_0416500 | copper-transporting ATPase |
Plasmodium falciparum | PF3D7_0904900 | copper-transporting ATPase |
Plasmodium knowlesi | PKNH_0702600 | copper-transporting ATPase, putative |
Saccharomyces cerevisiae | YDR270W | Cu(2+)-transporting P-type ATPase CCC2 |
Schistosoma japonicum | Sjp_0000890 | Copper-transporting ATPase 2, putative |
Schistosoma japonicum | Sjp_0000900 | Copper-transporting ATPase 2, putative |
Schistosoma japonicum | Sjp_0000920 | ko:K01533 Cu2+-exporting ATPase [EC3.6.3.4], putative |
Schistosoma mansoni | Smp_144970 | copper ABC transporter ATPase |
Schmidtea mediterranea | mk4.000189.02 | |
Schmidtea mediterranea | mk4.003571.02 | |
Schmidtea mediterranea | mk4.002977.02 | |
Schmidtea mediterranea | mk4.003552.00 | Atp7a protein |
Schmidtea mediterranea | mk4.000189.03 | Atp7a protein |
Schmidtea mediterranea | mk4.000189.00 | |
Schmidtea mediterranea | mk4.019004.00 | Putative copper-transporting atpase 1, 2 |
Trypanosoma brucei gambiense | Tbg972.11.1330 | copper-transporting ATPase-like protein, putative |
Trypanosoma brucei | Tb927.11.1260 | copper-transporting ATPase-like protein, putative |
Trypanosoma congolense | TcIL3000.11.1210 | copper-transporting ATPase-like protein, putative |
Trypanosoma cruzi | TcCLB.509015.10 | copper-transporting ATPase, putative |
Trypanosoma cruzi | TcCLB.511445.160 | copper-transporting ATPase-like protein, putative |
Trypanosoma cruzi | TcCLB.503703.50 | copper-transporting ATPase-like protein, putative |
Trypanosoma cruzi | TcCLB.503893.10 | copper-transporting ATPase-like protein, putative |
Toxoplasma gondii | TGME49_201150 | heavy metal translocating P-type ATPase subfamily protein |
Treponema pallidum | TP1036 | cation-transporting ATPase, P-type |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu93 | Mycobacterium tuberculosis | non-essential | nmpdr |
mtu984 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb11.47.0023 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.47.0023 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.47.0023 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.47.0023 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0484 | Escherichia coli | non-essential | goodall |
CELE_Y76A2A.2 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_Y76A2A.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y76A2A.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_Y76A2A.2 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_201150 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Trypanosoma cruzi | P-type H+-ATPase, putative | 645 aa | 27.6% | 548 aa | Compounds | References |
1 literature reference was collected for this gene.