Detailed view for Rv1028c

Basic information

TDR Targets ID: 6279
Mycobacterium tuberculosis, PROBABLE SENSOR PROTEIN KDPD

Source Database / ID: Tuberculist / Rv1028c 

pI: 5.8534 | Length (AA): 861 | MW (Da): 92717 | Number of Paralogs: 0

EC number(s): 2.7.13.3 | Enzyme, KEGG, Brenda (mouse over to display more information)
2.7.3.- | Enzyme, KEGG, Brenda (mouse over to display more information)

Signal peptide: N | GPI Anchor: (Show evidence) | Predicted trans-membrane segments: 3

Pfam domains

PF00512   HisKA
PF00582   Usp
PF02702   KdpD

Gene Ontology

Component: (mouse over links to read term descriptions)

GO:0016020   membrane  

Function: (mouse over links to read term descriptions)

GO:0005524   ATP binding  
GO:0004871   signal transducer activity  
GO:0004673   protein histidine kinase activity  
GO:0000155   two-component sensor activity  

Process: (mouse over links to read term descriptions)

GO:0018106   peptidyl-histidine phosphorylation  
GO:0016310   phosphorylation  
GO:0007165   signal transduction  
GO:0006950   response to stress  
Metabolic Pathways

Two-component system (KEGG)

Functional classes

No functional classes assigned to this gene.

Structural information
Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope

Modbase 3D models: 0
no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

Upregulation ranking: this gene ranks in the mid 40-60% group of genes.
Shows this level of upregulation in: Dormant phase.

Upregulation ranking: this gene ranks in the lower 20-40% group of genes.
Shows this level of upregulation in: Dormant phase.

References
murphy: Identification of gene targets against dormant phase Mycobacterium tuberculosis infections..
hasan: Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis..

Antigenicity

Number of putative antigenic epitopes: 36
Cumulative epitope score: 41.0
Normalized epitope score: 4.8
Percentile: 51.1 (this protein belongs to the top 48.9% proteins in the genome of Mycobacterium tuberculosis, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL 4 cluster: OG4_20474
Number of Paralogs: 0

Ortholog group members from selected species:
Escherichia coli K12 NP_415223.1   fused sensory histidine kinase in two-component regulatory s... |   OrthoMCL
Mycobacterium tuberculosis Rv1028c (this record).   PROBABLE SENSOR PROTEIN KDPD... |   OrthoMCL

Essentiality Rv1028c has essentiality data
Gene/Ortholog: mtu1044 (OG4_20474); Phenotype: non-essential; Source study: nmpdr
Gene/Ortholog: eco673 (OG4_20474); Phenotype: undefined; Source study: blattner
Gene/Ortholog: eco673 (OG4_20474); Phenotype: non-essential; Source study: gerdes
Gene/Ortholog: eco673 (OG4_20474); Phenotype: non-essential; Source study: keio
Gene/Ortholog: eco673 (OG4_20474); Phenotype: non-essential; Source study: shigen

[+/–]   Show essentiality data references.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

  • Curated from literature

    No chemical compounds associated to this gene

  • Predicted associations

    • By orthology to known druggable targets

    • From ChEMBL

      ChEMBL Species Known druggable target Reference Linked compounds
      No orthologous druggable targets
    • By sequence similarity to non orthologous druggable targets

    • No additional associated druggable targets
  • Assayability

    Assay information

    No assay information for this target.

    Reagent availability

    No reagent availability information for this target.

    Bibliographic references

    21 literature references were collected for this gene.

    If you have references for this gene, please enter them in a user comment (below) or contact us.

    User comments

    No user comments are available for this gene.

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