Detailed view for Rv1165

Basic information

TDR Targets ID: 981324
Mycobacterium tuberculosis, Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein)
Source Database / ID:  Tuberculist 

pI: 5.5355 | Length (AA): 628 | MW (Da): 67548 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 620 5a9v (A) 4 600 47.00 0 1 1.37557 0.53
5 150 4ac9 (C) 7 146 31.00 0.0000005 1 0.498784 -0.27
322 618 3e3x (A) 26 324 47.00 0 1 0.96123 0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128930)

Species Accession Gene Product
Arabidopsis thaliana AT5G13650   putative TypA-like translation elongation factor SVR3
Arabidopsis thaliana AT2G31060   elongation factor family protein
Babesia bovis BBOV_IV007720   GTP binding protein, putative
Dictyostelium discoideum DDB_G0276121   hypothetical protein
Escherichia coli b3871   GTP-binding protein
Leishmania braziliensis LbrM.25.0130   elongation factor, putative
Leishmania donovani LdBPK_250130.1   elongation factor, putative
Leishmania infantum LinJ.25.0130   elongation factor, putative
Leishmania major LmjF.25.0130   elongation factor, putative
Leishmania mexicana LmxM.25.0130   elongation factor, putative
Mycobacterium leprae ML1498c   POSSIBLE GTP-BINDING TRANSLATION ELONGATION FACTOR TYPA (TYROSINE PHOSPHORYLATED PROTEIN A) (GTP-BINDING PROTEIN)
Mycobacterium tuberculosis Rv1165   Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein)
Mycobacterium ulcerans MUL_1009   GTP-binding translation elongation factor TypA
Neospora caninum NCLIV_012820   GTP-binding protein TypA, related
Oryza sativa 4327008   Os01g0752700
Oryza sativa 4329037   Os02g0285800
Plasmodium berghei PBANKA_1421900   GTP-binding translation elongation factor, putative
Plasmodium falciparum PF3D7_0715600   GTP-binding translation elongation factor tu family protein, putative
Plasmodium knowlesi PKNH_1424600   GTP-binding translation elongation factor tu family protein, putative
Plasmodium vivax PVX_122985   GTP-binding protein TypA, putative
Plasmodium yoelii PY02880   elongation factor Tu family protein-related
Schmidtea mediterranea mk4.047253.02  
Trypanosoma brucei gambiense Tbg972.11.60   elongation factor, putative
Trypanosoma brucei Tb427tmp.03.0940   elongation factor, putative
Trypanosoma brucei Tb927.11.190   elongation factor, putative
Trypanosoma cruzi TcCLB.504109.150   elongation factor, putative
Toxoplasma gondii TGME49_301380   elongation factor Tu GTP binding domain-containing protein
Theileria parva TP03_0279   GTP-binding elongation factor, putative
Wolbachia endosymbiont of Brugia malayi Wbm0061   stress response membrane GTPase

Essentiality

Rv1165 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.03.0940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.03.0940 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.03.0940 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.03.0940 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3871 Escherichia coli non-essential goodall
PBANKA_1421900 Plasmodium berghei Essential plasmo
TGME49_301380 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv1165 (Mycobacterium tuberculosis), Possible GTP-binding translation elongation factor TypA (tyrosine phosphorylated protein A) (GTP-binding protein)
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