Detailed view for Rv1193

Basic information

TDR Targets ID: 980201
Mycobacterium tuberculosis, Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Source Database / ID:  Tuberculist 

pI: 6.3404 | Length (AA): 473 | MW (Da): 49488 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 458 3nyq (A) 4 471 52.00 0 1 1.61427 -0.81
5 472 3cw9 (A) 7 501 33.00 0 1 1.34953 -0.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129266)

Species Accession Gene Product
Arabidopsis thaliana AT3G16170   malonate--CoA ligase
Brugia malayi Bm1_28790   AMP-binding enzyme family protein
Caenorhabditis elegans CELE_F41C3.3   Protein ACS-11
Caenorhabditis elegans CELE_C50H11.1   Protein ACS-21
Dictyostelium discoideum DDB_G0289539   hypothetical protein
Drosophila melanogaster Dmel_CG18155   CG18155 gene product from transcript CG18155-RB
Homo sapiens ENSG00000176715   acyl-CoA synthetase family member 3
Leishmania braziliensis LbrM.28.1230   long-chain-fatty-acid-CoA ligase, putative
Leishmania donovani LdBPK_281250.1   long-chain-fatty-acid-coA ligase protein,putative
Leishmania infantum LinJ.28.1250   long-chain-fatty-acid-CoA ligase, putative
Leishmania major LmjF.28.1150   long-chain-fatty-acid-CoA ligase, putative
Leishmania mexicana LmxM.28.1150   long-chain-fatty-acid-CoA ligase, putative
Loa Loa (eye worm) LOAG_04219   hypothetical protein
Mycobacterium leprae ML1051   PROBABLE FATTY-ACID-CoA LIGASE FADD36 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)
Mus musculus ENSMUSG00000015016   acyl-CoA synthetase family member 3
Mycobacterium tuberculosis Rv1193   Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Mycobacterium ulcerans MUL_0943   acyl-CoA synthetase
Oryza sativa 4327020   Os01g0761300
Onchocerca volvulus OVOC2169  
Trypanosoma brucei gambiense Tbg972.11.8720   long-chain-fatty-acid-CoA ligase, putative
Trypanosoma brucei Tb927.11.7530   long-chain-fatty-acid-CoA ligase, putative
Trypanosoma congolense TcIL3000.11.8130   long-chain-fatty-acid-CoA ligase, putative
Trypanosoma cruzi TcCLB.511693.100   long-chain-fatty-acid-CoA ligase, putative
Trypanosoma cruzi TcCLB.503559.100   long-chain-fatty-acid-CoA ligase, putative

Essentiality

Rv1193 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.5520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.5520 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.5520 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.5520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv1193 (Mycobacterium tuberculosis), Probable fatty-acid-CoA ligase FadD36 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Title for this comment
Comment