Detailed view for Rv1391

Basic information

TDR Targets ID: 981230
Mycobacterium tuberculosis, Probable DNA/pantothenate metabolism flavoprotein homolog Dfp
Source Database / ID:  Tuberculist 

pI: 7.1285 | Length (AA): 418 | MW (Da): 43545 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02441  
PF04127  

Gene Ontology

Mouse over links to read term descriptions.
GO:0003824   catalytic activity  

Metabolic Pathways

Pantothenate and CoA biosynthesis (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 235 5h75 (D) 8 228 23.00 0 1 0.767955 -0.11
9 173 1g63 (A) 3 168 21.00 0 1 0.672237 -0.74
189 413 4qji (A) 185 409 85.00 0 1 1.43558 -0.44

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127040)

Species Accession Gene Product
Arabidopsis thaliana AT1G48605   putative phosphopantothenoylcysteine decarboxylase
Arabidopsis thaliana AT3G18030   phosphopantothenoylcysteine decarboxylase
Babesia bovis BBOV_II006900   flavoprotein domain containing protein
Brugia malayi Bm1_12615   Flavoprotein
Brugia malayi Bm1_22710   Flavoprotein
Candida albicans CaO19.3260   involved in cell cycle control and ion homeostasis
Candida albicans CaO19.10770   involved in cell cycle control and ion homeostasis
Caenorhabditis elegans CELE_F25H9.6   Protein F25H9.6
Cryptosporidium hominis Chro.30116   flavoprotein
Cryptosporidium parvum cgd3_870   flavoprotein, putative
Dictyostelium discoideum DDB_G0278413   phosphopantothenoylcysteine decarboxylase
Drosophila melanogaster Dmel_CG30290   Phosphopantothenoylcysteine decarboxylase
Escherichia coli b3639   fused 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase, FMN-binding
Echinococcus granulosus EgrG_000871700   phosphopantothenoylcysteine decarboxylase
Entamoeba histolytica EHI_092330   phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, putative
Entamoeba histolytica EHI_164490   phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase, putative
Echinococcus multilocularis EmuJ_000871700   phosphopantothenoylcysteine decarboxylase
Homo sapiens ENSG00000138621   phosphopantothenoylcysteine decarboxylase
Leishmania braziliensis LbrM.30.1590   hypothetical protein, conserved
Leishmania donovani LdBPK_301550.1   phosphopantothenoylcysteine decarboxylase, putative
Leishmania infantum LinJ.30.1550   hypothetical protein, conserved
Leishmania major LmjF.30.1540   hypothetical protein, conserved
Leishmania mexicana LmxM.29.1540   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02248   hypothetical protein
Mycobacterium leprae ML0543   Probable DNA/pantothenate metabolism flavoprotein homolog Dfp
Mus musculus ENSMUSG00000063849   phosphopantothenoylcysteine decarboxylase
Mycobacterium tuberculosis Rv1391   Probable DNA/pantothenate metabolism flavoprotein homolog Dfp
Mycobacterium ulcerans MUL_1790   bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Neospora caninum NCLIV_017870   hypothetical protein
Oryza sativa 4340408   Os06g0199500
Onchocerca volvulus OVOC7231  
Onchocerca volvulus OVOC7232  
Plasmodium berghei PBANKA_0714700   phosphopantothenoylcysteine decarboxylase, putative
Plasmodium falciparum PF3D7_0816100   phosphopantothenoylcysteine decarboxylase, putative
Plasmodium knowlesi PKNH_0504300   phosphopantothenoylcysteine decarboxylase, putative
Plasmodium vivax PVX_089600   phosphopantothenoylcysteine decarboxylase, putative
Plasmodium yoelii PY00571   Flavoprotein, putative
Saccharomyces cerevisiae YKL088W   phosphopantothenoylcysteine decarboxylase complex subunit CAB3
Schistosoma japonicum Sjp_0003980   ko:K01598 phosphopantothenoylcysteine decarboxylase [EC4.1.1.36], putative
Schistosoma mansoni Smp_027210   hypothetical protein
Schmidtea mediterranea mk4.000359.05  
Schmidtea mediterranea mk4.053877.00  
Trypanosoma brucei gambiense Tbg972.6.2730   hypothetical protein, conserved
Trypanosoma brucei Tb927.6.2940   phosphopantothenoylcysteine decarboxylase, putative
Trypanosoma congolense TcIL3000_6_2440   phosphopantothenoylcysteine decarboxylase, putative
Trypanosoma cruzi TcCLB.507021.110   phosphopantothenoylcysteine decarboxylase, putative
Trypanosoma cruzi TcCLB.511751.210   phosphopantothenoylcysteine decarboxylase, putative
Toxoplasma gondii TGME49_242880   flavoprotein
Trichomonas vaginalis TVAG_020500   phosphopentothenoylcysteine decarboxylase, putative

Essentiality

Rv1391 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.2940 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.2940 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.2940 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.6.2940 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b3639 Escherichia coli essential goodall
CELE_F25H9.6 Caenorhabditis elegans larval arrest wormbase
CELE_F25H9.6 Caenorhabditis elegans slow growth wormbase
YKL088W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0714700 Plasmodium berghei Dispensable plasmo
TGME49_242880 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv1391 (Mycobacterium tuberculosis), Probable DNA/pantothenate metabolism flavoprotein homolog Dfp
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