Detailed view for Rv1488

Basic information

TDR Targets ID: 981101
Mycobacterium tuberculosis, Possible exported conserved protein
Source Database / ID:  Tuberculist 

pI: 6.1356 | Length (AA): 381 | MW (Da): 41250 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01145  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 222 3bk6 (A) 57 218 41.00 0 1 0.955571 -0.66
64 172 2rpb (A) 65 173 49.00 0 1 0.958589 -1.05
65 172 4fvg (A) 94 201 39.00 0 1 0.922965 -1.72
309 374 3v6i (B) 38 105 23.00 0.94 0.05 0.384628 -0.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126714)

Species Accession Gene Product
Arabidopsis thaliana AT4G27585   SPFH/Band 7/PHB domain-containing membrane-associated protein
Arabidopsis thaliana AT5G54100   SPFH/Band 7/PHB domain-containing membrane-associated protein
Babesia bovis BBOV_I003370   stomatin-like protein, putative
Brugia malayi Bm1_19615   Mechanosensory protein 2
Brugia malayi Bm1_16790   SD03319p
Candida albicans CaO19.4079   potential SPFH domain, similar to mouse somatostatin-like protein SLP2
Candida albicans CaO19.11560   potential SPFH domain, similar to mouse somatostatin-like protein SLP2
Candida albicans CaO19.7296   similar to fungal and archaebacterial somatostatin-like proteins
Caenorhabditis elegans CELE_F32A6.5   Protein STO-2, isoform A
Caenorhabditis elegans CELE_F08C6.4   Protein STO-1, isoform A
Caenorhabditis elegans CELE_F30A10.5   Protein STL-1, isoform A
Caenorhabditis elegans CELE_F14D12.4   Protein MEC-2, isoform C
Dictyostelium discoideum DDB_G0274345   hypothetical protein
Dictyostelium discoideum DDB_G0290995   hypothetical protein
Dictyostelium discoideum DDB_G0270694   hypothetical protein
Drosophila melanogaster Dmel_CG7635   CG7635 gene product from transcript CG7635-RA
Drosophila melanogaster Dmel_CG33253   CG33253 gene product from transcript CG33253-RA
Drosophila melanogaster Dmel_CG2970   CG2970 gene product from transcript CG2970-RA
Drosophila melanogaster Dmel_CG42540   CG42540 gene product from transcript CG42540-RB
Escherichia coli b0489   PHB domain membrane-anchored putative protease
Echinococcus granulosus EgrG_000450500   MEChanosensory abnormality family member
Echinococcus granulosus EgrG_000194700   stomatin
Echinococcus granulosus EgrG_000764700   mechanosensory protein 2
Echinococcus granulosus EgrG_000469900   mechanosensory protein 2
Echinococcus granulosus EgrG_000951400   stomatin protein 2
Echinococcus multilocularis EmuJ_000194700   stomatin
Echinococcus multilocularis EmuJ_000469900   mechanosensory protein 2
Echinococcus multilocularis EmuJ_000450500   MEChanosensory abnormality family member
Echinococcus multilocularis EmuJ_000764700   mechanosensory protein 2
Echinococcus multilocularis EmuJ_000951400   stomatin protein 2
Homo sapiens ENSG00000165283   stomatin (EPB72)-like 2
Homo sapiens ENSG00000148175   stomatin
Homo sapiens ENSG00000133115   stomatin (EPB72)-like 3
Leishmania braziliensis LbrM.05.1040   stomatin-like protein
Leishmania donovani LdBPK_051040.1   stomatin-like protein
Leishmania infantum LinJ.05.1040   stomatin-like protein
Leishmania major LmjF.05.1040   stomatin-like protein
Leishmania mexicana LmxM.05.1040   stomatin-like protein
Loa Loa (eye worm) LOAG_06519   hypothetical protein
Loa Loa (eye worm) LOAG_07695   stomatin-like protein 2
Loa Loa (eye worm) LOAG_03876   hypothetical protein
Loa Loa (eye worm) LOAG_08946   mechanosensory protein 2
Mycobacterium leprae ML1802c   POSSIBLE EXPORTED CONSERVED PROTEIN
Mus musculus 229277   stomatin (Epb7.2)-like 3
Mus musculus ENSMUSG00000028455   stomatin (Epb7.2)-like 2
Mus musculus ENSMUSG00000026880   stomatin
Mycobacterium tuberculosis Rv1488   Possible exported conserved protein
Neospora caninum NCLIV_005610   Membrane protein, related
Oryza sativa 4344707   Os08g0158500
Onchocerca volvulus OVOC1865   Mechanosensory protein 2 homolog
Onchocerca volvulus OVOC2280  
Plasmodium berghei PBANKA_0807100   stomatin-like protein
Plasmodium falciparum PF3D7_0318100   stomatin-like protein
Plasmodium knowlesi PKNH_0823700   stomatin-like protein
Plasmodium vivax PVX_095325   stomatin-like protein
Plasmodium yoelii PY03188   SPFH domain / Band 7 family, putative
Schistosoma japonicum Sjp_0030930   Erythrocyte band 7 integral membrane protein, putative
Schistosoma japonicum Sjp_0056460   Mechanosensory protein 2, putative
Schistosoma japonicum Sjp_0066860   Mechanosensory protein 2, putative
Schistosoma japonicum Sjp_0302870   Stomatin-like protein 2, putative
Schistosoma mansoni Smp_122810   stomatin-related
Schistosoma mansoni Smp_066520   stomatin-related
Schistosoma mansoni Smp_072640   stomatin-related
Schmidtea mediterranea mk4.024732.00   Stomatin-2
Schmidtea mediterranea mk4.014996.00   SPFH domain / Band 7 family protein,putative
Schmidtea mediterranea mk4.022912.00  
Schmidtea mediterranea mk4.006318.00   SPFH domain / Band 7 family protein,putative
Schmidtea mediterranea mk4.000339.01   SPFH domain / Band 7 family protein,putative
Schmidtea mediterranea mk4.000241.00   Stomatin-like protein 2, mitochondrial
Schmidtea mediterranea mk4.011666.00  
Schmidtea mediterranea mk4.007362.00   Podocin
Schmidtea mediterranea mk4.021161.00   SPFH domain / Band 7 family protein,putative
Schmidtea mediterranea mk4.012803.00  
Schmidtea mediterranea mk4.005777.00   SPFH domain / Band 7 family protein,putative
Schmidtea mediterranea mk4.014634.00  
Schmidtea mediterranea mk4.006350.02   Stomatin-3
Schmidtea mediterranea mk4.016769.01   Stomatin-2
Schmidtea mediterranea mk4.002400.02   SPFH domain / Band 7 family protein,putative
Trypanosoma brucei gambiense Tbg972.5.540   stomatin-like protein, putative
Trypanosoma brucei Tb927.5.520   stomatin-like protein, putative
Trypanosoma congolense TcIL3000_5_200   stomatin-like protein, putative
Trypanosoma cruzi TcCLB.508397.30   SPFH domain / Band 7 family protein, putative
Trypanosoma cruzi TcCLB.509885.30   SPFH domain / Band 7 family protein, putative
Toxoplasma gondii TGME49_222210   SPFH domain / Band 7 family protein
Theileria parva TP03_0186   hypothetical protein, conserved

Essentiality

Rv1488 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.520 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.520 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.5.520 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0489 Escherichia coli non-essential goodall
CELE_F30A10.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_F30A10.5 Caenorhabditis elegans larval arrest wormbase
CELE_F30A10.5 Caenorhabditis elegans larval lethal wormbase
CELE_F30A10.5 Caenorhabditis elegans sterile wormbase
PBANKA_0807100 Plasmodium berghei Dispensable plasmo
TGME49_222210 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Rv1488 (Mycobacterium tuberculosis), Possible exported conserved protein
Title for this comment
Comment