pI: 6.3736 |
Length (AA): 407 |
MW (Da): 44669 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 191 | 2f6r (A) | 63 | 255 | 31.00 | 0 | 1 | 0.889387 | -0.44 |
2 | 190 | 1uf9 (A) | 9 | 191 | 36.00 | 0 | 1 | 0.846473 | 0.21 |
4 | 206 | 1n3b (A) | 5 | 201 | 33.00 | 0 | 1 | 0.643871 | 0.61 |
4 | 205 | 1vht (A) | 5 | 205 | 32.00 | 0 | 1 | 0.919415 | -0.32 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Dormant phase. | hasan |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | murphy |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
Ortholog group members (OG5_127254)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G27490 | dephospho-CoA kinase |
Babesia bovis | BBOV_IV009580 | dephospho-CoA kinase, putative |
Brugia malayi | Bm1_18905 | dephospho-CoA kinase family protein |
Candida albicans | CaO19.11488 | similar to S. cerevisiae YDR196C |
Candida albicans | CaO19.4005 | similar to S. cerevisiae YDR196C |
Caenorhabditis elegans | CELE_T05G5.5 | Protein T05G5.5, isoform C |
Cryptosporidium hominis | Chro.20045 | COG0237: dephospho-CoA kinase |
Cryptosporidium parvum | cgd2_380 | COG0237: dephospho-CoA kinase |
Chlamydia trachomatis | CT_492 | dephospho-CoA kinase |
Dictyostelium discoideum | DDB_G0285525 | dephospho-CoA kinase |
Drosophila melanogaster | Dmel_CG1939 | Dephospho-CoA kinase |
Escherichia coli | b0103 | dephospho-CoA kinase |
Entamoeba histolytica | EHI_040840 | dephospho-CoA kinase, putative |
Echinococcus multilocularis | EmuJ_000154100 | dephospho-CoA kinase, putative |
Giardia lamblia | GL50803_16483 | Dephospho-CoA kinase |
Homo sapiens | ENSG00000172992 | dephospho-CoA kinase domain containing |
Leishmania braziliensis | LbrM.22.1430 | dephospho-CoA kinase, putative |
Leishmania donovani | LdBPK_221380.1 | dephospho-CoA kinase, putative |
Leishmania infantum | LinJ.22.1380 | dephospho-CoA kinase, putative |
Leishmania major | LmjF.22.1530 | dephospho-CoA kinase, putative |
Leishmania mexicana | LmxM.22.1530 | dephospho-CoA kinase, putative |
Loa Loa (eye worm) | LOAG_07853 | dephospho-CoA kinase |
Mycobacterium leprae | ML1383 | Probable dephospho-CoA kinase CoaE (dephosphocoenzyme A kinase) |
Mus musculus | ENSMUSG00000020935 | dephospho-CoA kinase domain containing |
Mycobacterium tuberculosis | Rv1631 | Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase) |
Mycobacterium ulcerans | MUL_1613 | dephospho-CoA kinase/protein folding accessory domain-containing protein |
Oryza sativa | 4326028 | Os01g0360600 |
Plasmodium berghei | PBANKA_1307600 | dephospho-CoA kinase, putative |
Plasmodium falciparum | PF3D7_1443700 | dephospho-CoA kinase, putative |
Plasmodium knowlesi | PKNH_1238600 | dephospho-CoA kinase, putative |
Plasmodium vivax | PVX_118305 | dephospho-CoA kinase, putative |
Plasmodium yoelii | PY01909 | dephospho-CoA kinase, putative |
Saccharomyces cerevisiae | YDR196C | putative dephospho-CoA kinase |
Trypanosoma brucei gambiense | Tbg972.6.400 | dephospho-CoA kinase, putative |
Trypanosoma brucei | Tb927.6.710 | dephospho-CoA kinase, putative |
Trypanosoma congolense | TcIL3000_6_260 | dephospho-CoA kinase, putative |
Trypanosoma cruzi | TcCLB.511825.210 | dephospho-CoA kinase, putative |
Treponema pallidum | TP0296 | hypothetical protein |
Theileria parva | TP01_0811 | dephospho-CoA kinase, putative |
Trichomonas vaginalis | TVAG_083610 | Dephospho-CoA kinase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0259 | dephospho-CoA kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1659 this record | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.6.710 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.710 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.710 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.710 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0103 | Escherichia coli | essential | goodall |
YDR196C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1307600 | Plasmodium berghei | Essential | plasmo |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.