Detailed view for Rv1692

Basic information

TDR Targets ID: 8076
Mycobacterium tuberculosis, Probable phosphatase
Source Database / ID:  Tuberculist 

pI: 4.945 | Length (AA): 353 | MW (Da): 37011 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF13242   HAD-hyrolase-like
PF13344   Haloacid dehalogenase-like hydrolase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 344 4i9f (A) 2 344 99.99 0 1 2.14057 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 4I9F:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4I9G:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_127049)

Species Accession Gene Product
Arabidopsis thaliana AT5G47760   2-phosphoglycolate phosphatase 2
Arabidopsis thaliana AT5G36790   Haloacid dehalogenase-like hydrolase (HAD) superfamily protein
Arabidopsis thaliana AT5G36700   2-phosphoglycolate phosphatase 1
Brugia malayi Bm1_19505   haloacid dehalogenase-like hydrolase family protein
Candida albicans CaO19.4172   one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase
Candida albicans CaO19.4444   one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase
Candida albicans CaO19.11924   one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase
Candida albicans CaO19.11648   one of three genes similar to S. cerevisiae PHO13 (YDL236W) p-nitrophenyl phosphatase
Caenorhabditis elegans CELE_K09H11.7   Protein K09H11.7
Caenorhabditis elegans CELE_C53A3.2   Protein C53A3.2
Caenorhabditis elegans CELE_F44E7.2   Protein F44E7.2
Dictyostelium discoideum DDB_G0284737   hypothetical protein
Drosophila melanogaster Dmel_CG5567   CG5567 gene product from transcript CG5567-RA
Escherichia coli b0675   UMP phosphatase
Echinococcus granulosus EgrG_001078600   4 nitrophenylphosphatase
Echinococcus multilocularis EmuJ_001078600   4 nitrophenylphosphatase
Homo sapiens ENSG00000241360   pyridoxal (pyridoxine, vitamin B6) phosphatase
Homo sapiens ENSG00000184207   phosphoglycolate phosphatase
Leishmania braziliensis LbrM.31.2620   p-nitrophenylphosphatase, putative
Leishmania donovani LdBPK_312410.1   p-nitrophenylphosphatase, putative
Leishmania infantum LinJ.31.2420   p-nitrophenylphosphatase, putative
Leishmania infantum LinJ.31.2410   p-nitrophenylphosphatase, putative
Leishmania major LmjF.31.2340   p-nitrophenylphosphatase, putative
Leishmania mexicana LmxM.30.2340   p-nitrophenylphosphatase, putative
Loa Loa (eye worm) LOAG_02900   4-nitrophenylphosphatase
Mus musculus ENSMUSG00000043445   phosphoglycolate phosphatase
Mus musculus ENSMUSG00000022436   pyridoxal (pyridoxine, vitamin B6) phosphatase
Mycobacterium tuberculosis Rv1692   Probable phosphatase
Mycobacterium ulcerans MUL_1681   phosphatase
Neospora caninum NCLIV_042340   4-nitrophenylphosphatase, putative
Neospora caninum NCLIV_004110   hypothetical protein
Oryza sativa 9271010   Os12g0420000
Oryza sativa 4336245   Os04g0490800
Oryza sativa 4346547   Os09g0261300
Onchocerca volvulus OVOC11831   Putative phosphoglycolate\/pyridoxal phosphate phosphatase
Plasmodium berghei PBANKA_1421300   4-nitrophenylphosphatase, putative
Plasmodium falciparum PF3D7_0715000   4-nitrophenylphosphatase
Plasmodium knowlesi PKNH_1424000   4-nitrophenylphosphatase, putative
Plasmodium vivax PVX_122960   4-nitrophenylphosphatase, putative
Plasmodium yoelii PY01300   Phosphoglycolate phosphatase, eukaryotic
Saccharomyces cerevisiae YDL236W   Pho13p
Schistosoma japonicum Sjp_0212930   ko:K01101 4-nitrophenyl phosphatase [EC3.1.3.41], putative
Schistosoma mansoni Smp_030220   phosphoglycolate/pyridoxal phosphate phosphatase
Schmidtea mediterranea mk4.006053.03   Putative phosphoglycolate/pyridoxal phosphate phosphatase
Schmidtea mediterranea mk4.016915.00   Putative phosphoglycolate/pyridoxal phosphate phosphatase
Trypanosoma brucei gambiense Tbg972.8.7750   p-nitrophenylphosphatase, putative,phosphoglycolate phosphatase, putative
Trypanosoma brucei Tb927.8.7510   p-nitrophenylphosphatase, putative
Trypanosoma congolense TcIL3000_0_02570   p-nitrophenylphosphatase, putative
Trypanosoma congolense TcIL3000_8_7900   p-nitrophenylphosphatase, putative
Trypanosoma congolense TcIL3000_8_7760   p-nitrophenylphosphatase, putative
Trypanosoma cruzi TcCLB.511439.100   p-nitrophenylphosphatase, putative
Trypanosoma cruzi TcCLB.509261.10   p-nitrophenylphosphatase, putative
Toxoplasma gondii TGME49_209870   HAD hydrolase, family IIA protein
Trichomonas vaginalis TVAG_434390   pyridoxal-5-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_247920   4-nitrophenylphosphatase, putative
Trichomonas vaginalis TVAG_319310   pyridoxal-5-phosphate phosphatase, putative
Trichomonas vaginalis TVAG_391630   4-nitrophenylphosphatase, putative
Trichomonas vaginalis TVAG_382280   4-nitrophenylphosphatase, putative
Trichomonas vaginalis TVAG_242660   4-nitrophenylphosphatase, putative

Essentiality

Rv1692 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1721 this record Mycobacterium tuberculosis non-essential nmpdr
Tb927.8.7510 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7510 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.7510 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7510 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b0675 Escherichia coli non-essential goodall
TGME49_209870 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Rv1692 (Mycobacterium tuberculosis), Probable phosphatase
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