Detailed view for Rv1821

Basic information

TDR Targets ID: 980844
Mycobacterium tuberculosis, Possible preprotein translocase ATPase SecA2
Source Database / ID:  Tuberculist 

pI: 5.1138 | Length (AA): 808 | MW (Da): 88920 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01043  
PF07516  
PF07517  

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005524   ATP binding  
GO:0017038   protein import  
GO:0006886   intracellular protein transport  
GO:0006605   protein targeting  

Metabolic Pathways

Protein export (KEGG)
Bacterial secretion system (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
19 748 1nkt (A) 0 818 40.00 0 1 1.23807 -0.03
58 793 4uaq (A) 28 763 99.99 0 1 2.00749 -0.45
475 583 1hv8 (A) 241 336 21.00 0.23 0.97 0.322501 -0.75

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128579)

Species Accession Gene Product
Arabidopsis thaliana AT4G01800   protein translocase subunit secA
Arabidopsis thaliana AT1G21650   protein translocase subunit SECA2
Chlamydia trachomatis CT_701   protein translocase subunit SecA
Dictyostelium discoideum DDB_G0291406   hypothetical protein
Escherichia coli b0098   preprotein translocase subunit, ATPase
Mycobacterium leprae ML2082c   POSSIBLE PREPROTEIN TRANSLOCASE ATPase SECA2
Mycobacterium leprae ML0779   PROBABLE PREPROTEIN TRANSLOCASE SECA1 SUBUNIT
Mycobacterium tuberculosis Rv1821   Possible preprotein translocase ATPase SecA2
Mycobacterium tuberculosis Rv3240c   Probable preprotein translocase SecA1 1 subunit
Mycobacterium ulcerans MUL_3040   preprotein translocase subunit SecA
Mycobacterium ulcerans MUL_2576   preprotein translocase subunit SecA
Oryza sativa 4349987   Os11g0195100
Oryza sativa 4327279   Os01g0321300
Schistosoma mansoni Smp_109540   hypothetical protein
Schmidtea mediterranea mk4.035831.00  
Trypanosoma congolense TcIL3000_0_46420   SecA DEAD-like domain containing protein, putative
Trypanosoma congolense TcIL3000_0_02780   SecA DEAD-like domain containing protein, putative
Trypanosoma congolense TcIL3000_0_24270   SecA DEAD-like domain containing protein, putative
Trypanosoma congolense TcIL3000_0_36670   SecA DEAD-like domain containing protein, putative
Trypanosoma congolense TcIL3000_0_41820   SecA DEAD-like domain containing protein, putative
Treponema pallidum TP0379   preprotein translocase subunit SecA
Wolbachia endosymbiont of Brugia malayi Wbm0266   preprotein translocase subunit SecA

Essentiality

Rv1821 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0098 Escherichia coli essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Staphylococcus aureus (strain NCTC 8325) Protein translocase subunit SecA 1 Compounds References
Staphylococcus aureus (strain NCTC 8325) Protein translocase subunit SecA 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0566 0.9492 1
0.0569 0.388 0.3982
0.0569 0.388 0.3982
0.0569 0.388 0.3982
0.0525 0.5779 1
0.0525 0.5779 1
0.0459 0.5192 1
0.0525 0.5779 1
0.054 0.6151 1
0.0727 0.8696 1
0.0505 0.6753 1
0.0522 0.6756 1
0.0525 0.5779 1
0.0249 0.8868 1
0.0569 0.388 0.3982
0.0525 0.5718 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv1821 (Mycobacterium tuberculosis), Possible preprotein translocase ATPase SecA2
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