Detailed view for Rv1841c

Basic information

TDR Targets ID: 8174
Mycobacterium tuberculosis, Conserved hypothetical membrane protein
Source Database / ID:  Tuberculist 

pI: 6.8502 | Length (AA): 345 | MW (Da): 36685 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00571   CBS domain
PF01595   Domain of unknown function DUF21

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
175 333 3oi8 (A) 22 176 24.00 0 1 0.76557 -0.24
207 339 3lv9 (A) 16 144 23.00 0 1 0.750207 -1.02
211 339 3jtf (A) 76 199 34.00 0 1 0.794613 -0.67
227 337 1pvm (A) 12 127 21.00 0 1 0.653439 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_126632)

Species Accession Gene Product
Arabidopsis thaliana AT4G14240   CBS and DUF21 domain-containing protein
Arabidopsis thaliana AT2G14520   CBS and transporter associated domain-containing protein
Arabidopsis thaliana AT4G33700   hypothetical protein
Arabidopsis thaliana AT3G13070   CBS domain and transporter associated domain-containing protein
Arabidopsis thaliana AT1G03270   CBS domain-containing protein
Arabidopsis thaliana AT1G55930   CBS and transporter associated domain-containing protein
Arabidopsis thaliana AT5G52790   CBS domain-containing protein with a domain of unknown function (DUF21)
Arabidopsis thaliana AT1G47330   hypothetical protein
Arabidopsis thaliana AT4G14230   CBS domain-containing protein with a domain of unknown function (DUF21)
Babesia bovis BBOV_II006010   conserved unknown domain containing membrane protein
Brugia malayi Bm1_41980   ancient conserved domain protein 2
Brugia malayi Bm1_32240   ancient conserved domain protein 4
Brugia malayi Bm1_52965   ancient conserved domain protein 2
Candida albicans CaO19.6979   similar to S. cerevisiae MAM3 (YOL060C) needed for normal mitochondrial structure
Caenorhabditis elegans CELE_C33D12.2   Protein C33D12.2
Caenorhabditis elegans CELE_C52D10.12   Protein C52D10.12
Caenorhabditis elegans CELE_R04E5.2   Protein R04E5.2
Cryptosporidium hominis Chro.60221   CBS domain multi-pass transmembrane protein
Cryptosporidium hominis Chro.30153   hypothetical protein
Cryptosporidium parvum cgd3_1210   hypothetical protein having a signal peptide, conserved region, and three or more transmembrane domains
Cryptosporidium parvum cgd6_1840   cyclin M2-like membrane-associated protein with 4 transmembrane domains and 2 CBS domains
Chlamydia trachomatis CT_256   hypothetical protein
Chlamydia trachomatis CT_423   CBS domain-containing protein
Chlamydia trachomatis CT_257   hypothetical protein
Dictyostelium discoideum DDB_G0279807   hypothetical protein
Drosophila melanogaster Dmel_CG42595   unextended
Escherichia coli b0658   putative ion transport
Escherichia coli b4218   UPF0053 family inner membrane protein
Escherichia coli b4461   UPF0053 family inner membrane protein
Echinococcus granulosus EgrG_000779900   metal transporter cnnm2
Echinococcus granulosus EgrG_000828400   metal transporter cnnm2
Echinococcus multilocularis EmuJ_000779900   metal transporter cnnm2
Echinococcus multilocularis EmuJ_000828400   metal transporter cnnm2
Giardia lamblia GL50803_16803   Hypothetical protein
Homo sapiens ENSG00000119946   cyclin and CBS domain divalent metal cation transport mediator 1
Homo sapiens ENSG00000148842   cyclin and CBS domain divalent metal cation transport mediator 2
Homo sapiens ENSG00000158158   cyclin and CBS domain divalent metal cation transport mediator 4
Leishmania braziliensis LbrM.20.2210   hypothetical protein, conserved
Leishmania donovani LdBPK_342480.1   Domain of unknown function DUF21, putative
Leishmania infantum LinJ.34.2480   hypothetical protein, conserved
Leishmania major LmjF.34.2650   hypothetical protein, conserved
Leishmania mexicana LmxM.33.2650   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05642   hypothetical protein
Loa Loa (eye worm) LOAG_08918   hypothetical protein
Loa Loa (eye worm) LOAG_06883   hypothetical protein
Loa Loa (eye worm) LOAG_01980   hypothetical protein
Loa Loa (eye worm) LOAG_09519   hypothetical protein
Mus musculus ENSMUSG00000037408   cyclin M4
Mus musculus ENSMUSG00000025189   cyclin M1
Mus musculus ENSMUSG00000064105   cyclin M2
Mycobacterium tuberculosis Rv2366c   Probable conserved transmembrane protein
Mycobacterium tuberculosis Rv1842c   Conserved hypothetical membrane protein
Mycobacterium tuberculosis Rv1841c   Conserved hypothetical membrane protein
Neospora caninum NCLIV_001170   CBS domain multi-pass transmembrane protein, putative
Neospora caninum NCLIV_011630   hypothetical protein
Oryza sativa 4338701   Os05g0395300
Oryza sativa 4331466   Os03g0125800
Oryza sativa 4333362   Os03g0593200
Onchocerca volvulus OVOC6734  
Onchocerca volvulus OVOC3688  
Onchocerca volvulus OVOC10772  
Onchocerca volvulus OVOC1802  
Onchocerca volvulus OVOC12601  
Plasmodium berghei PBANKA_0832900   protein MAM3, putative
Plasmodium falciparum PF3D7_0932100   protein MAM3, putative
Plasmodium knowlesi PKNH_0730800   protein MAM3, putative
Plasmodium vivax PVX_087105   protein MAM3, putative
Plasmodium yoelii PY03208   putative ancient conserved domain protein
Plasmodium yoelii PY03209   hypothetical protein
Saccharomyces cerevisiae YOL060C   Mam3p
Schistosoma japonicum Sjp_0065700   Metal transporter CNNM2, putative
Schistosoma mansoni Smp_134460   ancient conserved domain protein 2 (cyclin m2)
Schmidtea mediterranea mk4.001979.05   Unextended
Schmidtea mediterranea mk4.043110.00   Putative annexin
Schmidtea mediterranea mk4.007949.02   Unextended
Schmidtea mediterranea mk4.014316.00   Unextended
Schmidtea mediterranea mk4.010239.00   Unextended
Schmidtea mediterranea mk4.026767.00   Putative annexin
Schmidtea mediterranea mk4.012313.00   Unextended
Schmidtea mediterranea mk4.013234.00   Unextended
Trypanosoma brucei gambiense Tbg972.4.1890   hypothetical protein, conserved
Trypanosoma brucei Tb927.4.1970   Domain of unknown function DUF21, putative
Trypanosoma congolense TcIL3000_4_1710   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510877.90   Domain of unknown function DUF21, putative
Toxoplasma gondii TGME49_211350   CBS domain-containing protein
Toxoplasma gondii TGME49_307580   CBS domain-containing protein
Treponema pallidum TP0028   hemolysin
Treponema pallidum TP0649   hemolysin (tlyC)
Treponema pallidum TP0027   hemolysin
Theileria parva TP02_0556   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0809   hemolysin
Wolbachia endosymbiont of Brugia malayi Wbm0070   Mg2+/Co2+ transporter

Essentiality

Rv1841c has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu1871 this record Mycobacterium tuberculosis non-essential nmpdr
Tb927.4.1970 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.1970 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.1970 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.1970 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0658 Escherichia coli non-essential goodall
b4461 Escherichia coli non-essential goodall
b4218 Escherichia coli non-essential goodall
PBANKA_0832900 Plasmodium berghei Slow plasmo
TGME49_211350 Toxoplasma gondii Probably essential sidik
TGME49_307580 Toxoplasma gondii Probably essential sidik
TGME49_211350 Toxoplasma gondii Essentiality uncertain sidik
TGME49_307580 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0008 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Rv1841c (Mycobacterium tuberculosis), Conserved hypothetical membrane protein
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